Objective To study the effect of estriol and its influence on the hemodynamics of patients with pelvic floor dysfunction after surgical treatment.Methods Ninety patients with pelvic floor dysfunction from September 2013 to December 2015,in Hubei Provincial Maternal and child health hospital department of urology were randomly divided into 2 groups,treatment group(45 cases)were treated by surgery combined with estriol,45 cases in control group were treated with surgery.The levels of pelvic organ prolapse,pelvic floor muscle strength,hemodynamic indexes(Qmax,MUP,MUCP,ALPP)in 2 groups were analyzed and compared before and after 24 weeks of treatment.Results Two groups of patients before treatment,pelvic organ prolapse,pelvic floor muscle strength,urodynamic index showed no significant differences(P>0.05);2 groups of patients after treatment,pelvic organ prolapse were improved in different degrees,the pelvic floor muscle strength obviously recovered,urodynamic indexes were increased in different the degree,difference before and after the treatment were statistically significant(P<0.05);after 24 weeks of treatment,the total efficiency of stress urinary incontinence in the treatment group up to 91.1％(41/45),significantly higher than the control group(68.9％,31/45),the difference was statistically significant(x2=6.944,P<0.05).Conclusion The curative effect of estriol combined with operation on pelvic floor dysfunction is better than that of operation.It can obviously improve the clinical symptoms of patients with pelvic floor dysfunction,and the curative effect is remarkable.%目的 研究盆底功能障碍性疾病患者手术治疗后应用雌三醇的效果及对尿流动力学指标的影响.方法 2013年9月-2015年12月湖北省妇幼保健院泌尿外科收治盆底功能障碍性疾病患者90例,采用抽签法随机均分为2组,联合组45例应用手术联合雌三醇治疗,对照组45例单纯手术治疗.对比分析2组患者治疗前后盆腔脏器脱垂程度、盆底肌力强度改善情况、尿流动力学指标(Qmax、MUP、MUCP、ALPP)变化情况及治疗24周后的临床疗效.结果 治疗前2组患者的盆腔脏器脱垂程度、盆底肌力强度、尿流动力学指标比较,差异均无统计学意义(P >0.05);治疗后2组患者的盆腔脏器脱垂程度均不同程度改善,盆底肌力强度明显得到恢复,尿流动力学指标均不同程度的增加,与治疗前比较差异均有统计学意义(P <0.05),且联合组患者上述指标的改善情况均优于对照组(P <0.05);治疗24周后联合组压力性尿失禁临床总有效率高达91.1％(41/45),明显高于对照组的68.9％(31/45),差异有统计学意义(x2=6.944,P <0.05).结论 雌三醇联合手术治疗盆底功能障碍性疾病患者疗效优于手术治疗,可明显改善患者的临床症状,疗效显著.
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