Objective To investigate the relationship between serum adiponectin, leptin ( LP) and urinary 8 iso prostaglanlin F2 alpha ( 8-iso-PGF2α) and pulmonary function in patients with chronic obstructive pulmonary disease ( COPD) in stable stage.Methods Choose from June 2014 to June 2015, 55 cases of stable COPD patients in Guangdong Province Yuebei people's Hospital as the observation group, compared with 55 cases of healthy volunteers as control group. The serum levels of adiponectin, LP and urine 8-iso-PGF2αin 2 groups were measured and the lung function was measured. Results Two groups of cholesterol, triglyceride glycerol, glucose, diastolic pressure, systolic blood pressure’ s difference were not statistically significant ( P >0.05);in observation group, the serum levels of adiponectin and LP levels were signifi-cantly lower than those in healthy control group, urinary 8-iso-PGF2αlevels were significantly higher than those in healthy control group ( P <0.05).I ~IV grade patients’pulmonary function:FEV1%, FEV1/FVC and serum levels of adiponectin and LP were gradually decreased, while the 8-iso-PGF2αlevels gradually increased, the differences were statistically signifi-cant ( P <0.05).8-iso-PGF2αand FEV1%, FVC%, FEV1/FVC showed negative correlation ( r =-0.687, r =-0.509, r =-0.731, P <0.05);serum adiponectin and FEV1%,FVC%,FEV1/FVC were positively correlated ( r =0.186, r =0.132, r =0.169, P <0.05);LP and FEV1%,FVC%,FEV1/FVC were positively correlated ( r =0.298, r =0.261, r =0.203, P <0.05).Conclusion The levels of serum adiponectin, LP and urine 8-iso-PGF2αwere closely related to the lung function, and the level of the three indices were strengthened during the treatment.%目的：探讨慢性阻塞性肺疾病（ COPD）患者稳定期血清脂联素、瘦素（ LP）及尿8异前列腺素F2α（8-iso-PGF2α）与肺功能的关系。方法选取2014年6月—2015年6月广东省粤北人民医院呼吸内科收治的稳定期COPD患者55例为观察组，同期健康志愿者55例为健康对照组。对2组对象血清脂联素、瘦素及尿8-iso-PGF2α水平进行检测，并测定肺功能。结果2组的胆固醇、三酰甘油、血糖、舒张压、收缩压比较，差异均无统计学意义（P ＞0构．05）；观察组血清脂联素水平和瘦素水平明显低于健康对照组，尿8-iso-PGF2α水平明显高于健康对照组（ P均＜0．05）。Ⅰ～Ⅳ级患者的肺功能指标FEV1％、FEV1／FVC以及血清脂联素、瘦素水平均逐渐下降，而尿8-iso-PGF2α水平逐渐上升，差异均有统计学意义（ P ＜0．05）。8-iso-PGF2α与FEV1％、FVC％、FEV1／FVC均呈显著负相关（ r ＝－0．687、－0．509、－0．731， P均＜0．05）；而血清脂联素与FEV1％、FVC％、FEV1／FVC均呈显著正相关（ r ＝0．186、0．132、0．169， P均＜0．05）；瘦素与FEV1％、FVC％、FEV1／FVC均呈显著正相关（ r ＝0．298、0．261、0．203， P均＜0．05）。结论血清脂联素、瘦素及尿8-iso-PGF2α水平均与肺功能之间密切相关，治疗过程中加强对三者的水平控制。
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