目的：分析先天性白血病患儿临床及随访特点，为先天性白血病临床治疗提供参考。方法回顾性分析2010年6月—2015年6月南华大学儿科学院／湖南省儿童医院新生儿病房收治先天性白血病患儿5例的临床特点及随访资料。结果5例患儿男4例，女1例。临床特点：皮肤包块2例，全身出血点2例，肝大巨脾3例，合并先天性心脏病2例，发热2例，重度贫血2例。实验室检查白细胞升高4例，正常1例，血小板降低2例。5例患儿均予对症支持治疗，住院3～37 d，出院后随访18个月～4 R．5年，其中患儿自然缓解3例，失访1例，死亡1例。结论先天性白血病病死率高，明确诊断、确定免疫分型后，如若不是复杂的染色体质量重排可保守支持治疗、长期随访。%Objective To analysis the clinical and follow-up characteristics of congenital leukemia in children and to provide reference for the clinical treatment of congenital leukemia.Methods Retrospective analysis from June 2010 to June 2015, the clinical features and follow-up data of five cases of children with congenital leukemia in Nanhua University child Sci-ences /Hunan Children's Hospital neonatal wards.Results 5 patients were 4 males and 1 female.Skin mass in 2 cases, 2 cases of systemic bleeding, liver splenomegaly in 3 cases, congenital heart disease in 2 cases, 2 cases of fever, severe anemia in 2 cases.Laboratory tests showed that leukocytosis in 4 cases, 1 case of normal, platelets decreased in 2 cases.5 cases of patients were treated with symptomatic and supportive treatment, average length of stay was 19.6 days, after discharge were followed up for 18 months to 4.5 years, of which three cases of children with a natural ease, lost follow up of 1 case, 1 death. Conclusion Congenital leukemia mortality is high, after diagnosis and determining the immune classification, if is not exclu-sive complex chromosome quality, can be treated with a conservative support treatment and long-term follow-up.
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