Objective To investigate the clinical efficacy of calcium combined with low dose aspirin therapy in pa-tients with mild preeclampsia.Methods 158 cases of mild preeclampsia from September 2012 to February 2014 in Xi'an High tech hospital for three subjects was treated.Based on a random number table, they were divided into observation group and control group, the control group was given conventional magnesium sulfate treatment observation group taking calcium ( Cal-trate) combined with low dose aspirin.After the observation of clinical symptoms and the patient's coagulation groups to im-prove the situation, 24h proteinuria, serum calcium and changes in blood pressure, treatment efficiency and the Apgar score. Results After treatment, the two groups have a headache, edema and visual abnormalities in patients with clinical symptoms were significantly improved, and the observation of clinical symptoms and improved coagulation than the control group ( P <0.05);2 group 24h blood pressure and proteinuria, serum calcium were improved, and the observation group 24h blood pres-sure and proteinuria, serum calcium than the control group, it were significant differences between the two groups ( P <0.05);2 group Fbg, APTT, PT were improved, and the observation group's Fbg, APTT, PT were different from the control group ( P <0.05); the treatment of the overall efficiency of the observation group (93.67%, 74/79) rate was higher (78.48%, 62/79), there were significant differences between the two groups ( P <0.05);two groups'abnormal fetal heart rate showed no significant difference in Apgar score ( P >0.05).Conclusion Mild preeclampsia be calcium combined with low dose aspirin treatment definite improvement in clinical symptoms and coagulation effect is obvious, and to improve the in vivo serum calcium levels, lower blood pressure, but had no effect on the fetus, it is a relatively good treatment plan.%目的：观察钙剂联合小剂量肠溶阿司匹林治疗轻度子痫前期患者的临床疗效。方法选取2012年9月—2014年2月西安高新医院产三科收治轻度子痫前期患者158例，依据随机数字表法分为观察组和对照组，每组79例，对照组予以传统的硫酸镁治疗，观察组服用钙剂（钙尔奇）联合小剂量的肠溶阿司匹林，均于终止妊娠前1周停用。观察治疗后2组患者的临床症状和凝血功能改善情况，24h蛋白尿、血清钙及血压的变化，治疗效果和新生儿Ap-gar评分。结果治疗后，2组患者头痛、水肿及视觉异常等临床症状较治疗前均有明显改善（ P ＜0．05），且观察组临床症状改善均优于对照组（ P ＜0．05）；2组患者治疗后血压和24h蛋白尿、血清钙较治疗前均有改善（ P ＜0．05），且观察组改善优于对照组（ P ＜0．05）；2组患者治疗后纤维蛋白原（Fbg）、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）较治疗前均有改善，且观察组Fbg、APTT、PT改善均优于对照组（ P ＜0．05）；观察组的治疗总有效率93．67％（74／79）显著高于对照组78．48％（62／79），2组比较差异有统计学意义（ P ＜0．05）；2组胎心率异常率、新生儿Apgar评分比较差异无统计学意义（ P ＞0．05）。结论轻度子痫前期患者予以钙剂联合小剂量阿司匹林的治疗效果确切，临床症状和凝血功能改善效果明显，并且能够提高患者体内血清钙水平，降低血压，同时对胎儿无影响，是一种较好的治疗方案。
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