Objective To evaluate the efficacy of antianxiety agents or antidepressants in the treatment of functional dyspepsia ( FD) .Methods Articles regarding the efficacy and safety of antianxiety agents or antidepressants were retrieved from PubMed, EMBASE, Web of Science, The Cochrane library, Chinese Journals Full text Database ( CNKI, China National Knowledge Infrastructure ) , Wan Fang Digital Journal Full text Database, and Database for Chinese Technical Periodical (VIP) to collect clinical randomized controlled trial (RCT) for FD treatment.Meta-analysis was performed by using Stata 12.0.Results A total of eight RCTs including 886 patients met the inclusion criteria.Meta-analysis results were as follows. Antianxiety agents or antidepressants were associated with a significant reduction in dyspepsia symptoms score compared with placebo therapy(SMD=-0.32,95%CI -0.636 to -0.004, P =0.047).Subgroup analysis indicated that the treatment effect of antianxiety agents for FD was superior to placebo(SMD=-0.47,95%CI -0.931 to -0.016, P =0.043),but an-tidepressants had no statistical difference compared with placebo(SMD=-0.23,95%CI -0.646 to 0.182, P =0.271).In terms of adverse reactions, antianxiety agents or antidepressants has low incidence of adverse reactions, being similar to place-bo(OR=1.25,95%CI 0.847 to 1.847, P =0.261).Conclusion Antianxiety agents may be effective and safe for FD treatment, but the role of antidepressants needs future study.%目的：系统评价抗焦虑或抗抑郁药辅助治疗功能性消化不良（ FD ）的疗效。方法计算机检索PubMed、EMBASE、Wed of Science、The Cochrane library、CNKI全文数据库、万方数据库以及中国科技期刊数据库，检索时间建库至2015年12月，搜集关于抗焦虑或抗抑郁药治疗FD的随机对照试验（RCT），采用Stata12．0对纳入的研究进行Meta分析。结果共8项RCT包含886例患者符合入选标准。 Meta分析结果显示：与安慰剂相比，抗焦虑或抗抑郁药能够降低消化不良症状总分，差异有统计学意义（SMD＝－0．32，95％CI －0．636～－0．004， P ＝0．047）；亚组分析显示，抗焦虑药对FD的治疗效果优于安慰剂（SMD＝－0．47，95％CI －0．931～－0．016， P ＝0．043），而抗抑郁药的疗效与安慰剂相比差异无统计学意义（SMD＝－0．23，95％CI －0．646～0．182， P ＝0．271）。在不良反应方面，抗焦虑或抗抑郁药不良反应发生率较低，与安慰剂相似（ OR＝1．25，95％CI 0．847～1．847， P ＝0．261）。结论抗焦虑药可能是治疗FD的有效药物，且较为安全，但抗抑郁药对FD的治疗作用有待进一步的探讨。
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