Objective To assess the ability of SPAN-100 score combining hs-CRP level in predicting risk of symp-tomatic intracerebral hemorrhage ( sICH) following the recombinant tissue plasminogen activator ( rtP-A) intravenous throm-bolysis (IVT) treatment in acute ischemic stroke (AIS) patients.Methods Ninety-three cases of AIS patients within 4 .5h of stroke onset who were treated in Department of Neurology , Hubei provincial Hospital of Integrated Chinese&Western Medi-cine between May 1st, 2012 to March 1st, 2016 were enrolled.According to the head CT or MR and the change of NIHSS score,they were divided in sICH group and non-sICH group.Univariate analysis was used to assess the differences of SPAN-100 score, hs-CRP and risk factors for cerebrovascular disease between sICH group and non -sICH group.Further, univariate and multivariate logistic regression analysis were used to assess the independent predicted factors affecting sICH .Receiver op-erating characteristic ( ROC) curve analysis and calculation of the area under the curve ( AUC) were applied to evaluate the performance of SPAN-100 score, hs-CRP level and SPAN-100 combined with hs-CRP level in predicting sICH .Results Uni-variate analysis of baseline data:the sICH group age( t =2.766, P =0.007), NIHSS score before IVT( t =3.679, P =0.000), systolic blood pressure before IVT( t =3.613, P =0.004), hs-CRP level( t =2.305, P =0.023)and SPAN-100 positive(χ2 =19.079, P =0.000)were higher than non-sICH group, all differences had statistical significances (all P <0.05).Univariate Pearson correlation analysis showed elderly age , high NIHSS score before IVT, high systolic blood pressure before IVT, high hs-CRP level and SPAN-100 positive had positive correlation of sICH ( r =0.278, r =0.360, r =0.248, r =0 L.235, r =0.453, all P <0.05).Take above factors to multivariate logistic regression analysis showed that elderly age (OR=1.171,95%CI 1.018-1.346),elevated hs-CRP level (OR=1.258, 95%CI 1.032-1.533) and SPAN-100 posi-tive (OR=9.729, 95%CI 1.386-68.277) were the independent prediction factors for risk of sICH .ROC curve analysis showed AUC (SPAN-100)=0.726 (95%CI 0.503-0.950), AUC (hs-CRP level) =0.711 (95%CI 0.501-0.921) and AUC (SPA-100 +hs-CRP level) =0.768 (95%CI 0.548-0.989), all P <0.05.Conclusion It demonstrated that the SPAN-100 score was a simple , easy to calculate and effective predictive sICH tools , combined with CRP HS detection can sig-nificantly improve the predictive value of sICH .%目的：分析SPAN-100评分联合高敏C-反应蛋白（ hs-CRP）预测缺血性脑卒中（ AIS）静脉溶栓（ IVT）后症状性颅内出血（ sICH）风险的价值。方法连续纳入2012年5月1日—2016年3月1日在湖北省中西医结合医院神经内科住院进行IVT治疗、并有完整临床资料的AIS患者93例，AIS发病4栽．5 h内应用rt-PA进行IVT治疗，按溶栓后复查头颅CT或MR和NIHSS评分变化分为sICH组（8例）和非non-sICH组（85例）。分析2组SPAN-100评分、hs-CRP及其相关脑血管病危险因素的差异，并进一步分析影响sICH发生的独立预测因素。采用受试者工作特征（ ROC）曲线分析计算曲线下面积（ AUC）及95％CI评价SPAN-100评分、hs-CRP和两者联合预测sICH发生的价值。结果2组基线资料分析表明，sICH组年龄、溶栓前NIHSS评分、溶栓前收缩压、hs-CRP水平和SPAN-100评分阳性明显高于non-sICH组（ t ＝2．766、3．679、3．613、2．305，χ2＝19．079， P均＜0．05）。单因素分析表明，年龄、溶栓前NIH-SS评分、溶栓前收缩压、hs-CRP水平和SPAN-100评分与sICH均呈正相关关系（ r ＝0．278、0．360、0．248、0．235、0．453， P均＜0．05）。多因素Logistic回归分析表明，年龄大（OR＝1．171，95％CI 1．018～1．346）、hs-CRP水平升高（OR＝1．258，95％CI 1．032～1．533）、SPAN-100评分阳性（OR＝9．729，95％CI 1．386～68．277）是发生sICH的独立预测因素。 ROC曲线分析表明，SPAN-100评分AUC ＝0．726（95％CI 0．503～0．950）、hs-CRP水平AUC＝0．711（95％CI 0．501～0．921）和两者联合AUC＝0．768（95％CI 0．548～0．989），差异均有统计学意义（ P ＜0．05）。结论 SPAN-100评分是一种简单、易计算、有效的预测sICH的工具，与hs-CRP联合检测可明显提高预测IVT后sICH的价值。
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