目的：探讨前列地尔注射液对短暂性脑缺血发作（ TIA）脑血流变化的影响。方法收集TIA患者121例，随机分为2组，加用前列地尔注射液（治疗组）61例与未加用前列地尔注射液（对照组）60例，治疗前后采用经颅多普勒超声（ TCD）检测并对比分析大脑中动脉（ MCA）、大脑前动脉（ ACA）、双侧椎动脉（ VA）及基底动脉（ BA）平均血流速度（Vm）的改善，并观察临床疗效。结果治疗组治愈率、总有效率分别为72 O．13％、98．36％，明显优于对照组的36．67％、90．00％，差异有统计学意义（ P ＜0．05）。2组治疗前MCA、ACA、VA、BA血流速度比较差异均无统计学意义（ P ＞0．05）；治疗后均较治疗前提高（ P ＜0．05， P ＜0．01），且观察组较对照组提高更显著（ P ＜0．05）。对照组治疗后颈总动脉内径、血流速度、斑块面积无显著改善，治疗组治疗后颈总动脉内径、血流速度显著改善且均优于对照组（ P ＜0．05），而斑块面积亦无显著改善。结论前列地尔注射液可显著提高TIA患者MCA、ACA、VA、BA血液流速及临床疗效。%Objective To investigate the effect of alprostadil injection on cerebral blood flow of transient ischemic at -tack ( TIA) .Methods Collected 121 cases of TIA ,they were randomly divided into two groups , alprostadil injection ( treat-ment group) in 61 cases, without the use alprostadil injection (control group) in 60 patients.Before and after treatment, u-sing transcranial Doppler ultrasound ( TCD) to detect and comparative analysis of the middle cerebral artery ( MCA) , anterior cerebral artery ( ACA) , bilateral vertebral artery ( VA) and basilar artery ( BA) mean velocity ( Vm) improvement and clini-cal efficacy.Results Cure rate and total effective rate were 72.13%, 98.36% in treatment group, significantly better than 36.67%, 90.00% in the control group, the difference was statistically significant ( P <0.05).Before treatment, MCA, ACA, VA, BA flow velocity difference in the two groups was not statistically significant ( P >0.05); after treatment, both groups were improved than before treatment ( P <0.05, P <0.01), and the observation group improved more significantly than in the control group ( P <0.05).Control group's neck artery diameter, flow velocity, plaque area was not improved sig-nificant after therapy , the treatment group's neck artery diameter , blood flow velocity was significantly improved and were bet-ter than the control group ( P <0.05), while no significant improvement in the plaque area .Conclusion Alprostadil injec-tion can significantly improve the MCA , ACA, VA, BA blood flow and clinical efficacy of TIA .
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