Objective To observe the effect of Chaiyujisheng decoction week therapy with soothing the liver and in-vigorating the kidney in the treatment of liver and kidney deficiency type hyperprolactinemia menstruation , and to explore its mechanism of action .Methods 60 cases of hyperprolactinemia late menstruation patients , randomly divided into treatment group (Chaiyujisheng decoction) and control group (bromocriptine) with 30 cases in each group.To observe the clinical cur-ative effect before and after treatment , TCM symptoms, blood prolactin ( PRL) and the association between hormone ( E2 , LH) , and compare the effects of the two therapy .Results Compared with before treatment , index scores of the 2 groups after treatment were improved, the difference was statistically significant ( P <0.05);treatment group in improving the menstrual cycle and symptom , breast distending pain , menstrual distending pain in the lower abdomen and other symptoms are signifi -cantly better than the control group ( P <0.05), the treatment group the total symptom score index was 81.0%, control group 33.0%.Compared with before treatment, the 2 groups after treatment PRL, P, LH, E2 levels decreased ( P <0.05), and the treatment group E2 levels significantly better than the control group ( P <0.05), there were no significant differences in FSH levels in the 2 groups before and after treatment ( P >0 .05 ) .The 2 group total effectiveness have statistics signifi-cance (86.7%vs.73.3%, P <0.05).Conclusion It demonstrated that the Chaiyujisheng decoction week therapy with soothing the liver and invigorating the kidney in treatment of hyperprolactinemia is safe , effective .%目的：观察自拟柴郁寄生汤疏肝补肾调周疗法治疗肝郁肾虚型高泌乳素血症月经后期的临床疗效，并探讨其作用机制。方法将60例高泌乳素血症月经后期患者，随机分为治疗组（柴郁寄生汤）和对照组（溴隐亭）各30例。观察临床综合疗效、治疗前后中医证候改善情况、血中泌乳素（ PRL）和相关性激素（ E2、LH）水平，并进行疗效比较。结果与治疗前比较，2组治疗后各项积分均有改善，差异有统计学意义（ P ＜0^．05）；治疗组在改善月经周期及腰膝酸软、乳房胀痛、经行少腹胀痛等症状方面疗效明显优于对照组（ P ＜0．05），治疗组总证候积分指数为81．0％，对照组为33．0％。与治疗前比较，2组治疗后PRL、P、LH、E2水平均降低（ P ＜0．05），且治疗组在改善E2水平疗效明显优于对照组（ P ＜0．05），2组FSH水平治疗后与治疗前比较差异无统计学意义（ P ＞0．05）。2组总有效率比较差异有统计学意义（86．7％vs．73．3％， P ＜0．05）。结论自拟柴郁寄生汤补肾疏肝调周疗法治疗高泌乳素血症安全、有效。
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