Objective To shirty the clinical effects of combined treatment about traditional Chinese medicine and western medicine in hepatic fibrosis ( HF ) with chronic hepatitis B ( CHB ). Methods 90 patients with CHB were randomly divided into observation group ( n =45 ) and control group( n =45 ), control group were treated with western medicine, and observation group were treated with integrated traditional Chinese and western medicine. Then liver function, CHB virological indicators, and HF serum marker changes before and after treatment were compared between the two groups. Results After the treatment, liver function, CHB virological indicators, and HF serum marker were significantly better than before both in the two groups ( P < 0. 05, P < 0. 01 ), and observation group were significantly better than control group after the treatment ( P < 0. 01 or P < 0. 05 ). Conclusion Combined treatment of traditional Chinese medicine and western medicine has good effects in HF with CHB, but the long term effects are unclear, and further research is needed to confirm it.%目的 探讨自拟方联合拉米夫定治疗慢性乙型病毒性肝炎肝纤维化的临床效果.方法 90例慢性乙型肝炎患者随机分观察组与对照组各45例,对照组给予拉米夫定等治疗,观察组在对照组基础上加用自拟中药方剂治疗,对比2组患者治疗前后肝功能、乙型肝炎病毒学指标及肝纤维化血清学标志物变化情况.结果 治疗后,2组患者肝功能、乙肝病毒学标志物及肝纤维化血清学标志物均明显好转(P<0.05,P＜0.01),且治疗后观察组显著优于对照组(P＜0.01或P＜0.05).结论 自拟方剂联合拉米夫定治疗慢性乙型肝炎肝纤维化疗效可靠,同时能够获得更高的病毒学指标转阴率,且肝功能恢复相对更好,值得临床推广应用.
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