目的 探讨老年单纯收缩期高血压(ISH)患者颈动脉内膜-中层厚度(IMT)与脉压(PP)及血清基质金属蛋白酶-9(MMP-9)之间的相关性.方法 收集ISH患者52例(ISH组)、混合性高血压(SDH)患者48例(SDH组)以及老年健康体检组50例(健康对照组),分别检测脉压(PP)、血MMP-9及IMT,分析三者之间的关系.结果 ISH组、SDH组PP、MMP-9水平及IMT均高于健康对照组(P＜0.01),且ISH组较SDH组高(P<0.05),IMT与SBP、DBP、PP及MMP-9呈正相关(r=0.333,r=0.263,r=0.573,r=0.742,P＜0.01).多元逐步回归分析表明,PP、MMP-9为IMT的独立危险因素(P<0.05).结论 ISH组患者颈动脉重构程度较SDH组重,PP及MMP-9水平升高与IMT增厚呈正相关,PP及MMP-9升高可能是造成动脉粥样硬化的重要因素.%Objective To investigate the relationship between the intima media thickness ( IMT ) of the carotid artery and pulse pressure( PP ), matrix metalloproteinase-9 ( MMP-9 ) in the elderly patients with ingenuous systolic hypertension ( ISH ) . Methods The levels of PP, MMP-9 and the IMT of carotid artery were detected and analyzed statistically in 52 elder ISH patients, 48 systolic and diastolic hypertension ( SDH ) patients and 50 healthy controls. Results The levels of PP and MMP-9 in two hypertension groups were significantly higher than those in normal controls ( P < 0.01 ), while those was higher in ISH group than SDH group ( P <0.05 ). The IMT of carotid artery was higher than that in normal controls, the levels of PP and matrix metalloproteinase-9 ( MMP-9 ) in the ISH group were higher than those in SDH group( P < 0. 05 ). Positive relationships were found between IMT and SBP, DBP, PP, and MMP-9 ( r =0. 333, r =0. 263, r =0. 573, r =0. 742, P < 0.01 ). Multiple regression analysis showed that PP,MMP-9 were independent risk factors of IMI( P <0.05 ). Conclusion In ISH patients, IMT level is correlated with level of MMP-9 and PP,PP and MMP-9 may be the risk factors of vascular remodeling.
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