目的 观察血清高敏C-反应蛋白(hs-CRP)浓度在非瓣膜性心房颤动合并脑栓塞与未合并脑栓塞患者间是否存在差异,以探讨hs-CRP对预测房颤合并脑栓塞的临床意义.方法 选择房颤患者216例,依据有无脑栓塞分为2组,并选择体检健康者100例作为健康对照组,检测血清hs-CRP.结果 房颤合并脑栓塞组的血清hs-CRP值明显高于房颤未合并脑栓塞组及健康对照组,差异有统计学意义(P<0.01).以hs-CRP>5.612 mg/L为阳性标准,房颤合并脑栓塞组与未合并脑栓塞组的检出阳性率比较差异亦有统计学意义(P<0.01) .hs-CRP明显升高的房颤患者发生脑栓塞的危险是hs-CRP不升高房颤患者的11.32倍.结论 房颤合并脑栓塞患者血清hs-CRP明显升高,hs-CRP升高是预测房颤合并脑栓塞的可靠指标.%Objective To assess whether there are differences in serum hs-CRP concentration between patients of AF combined with cerebral embolism and did not combine with cerebral embolism, and then investigate clinical significance of hsCRP in predicting AF combined with cerebral embolism. Methods According to atrial fibrillation with or without cerebral embolism, 216 patients were divided into two groups, and 100 healthy volunteers were enrolled as control group. The serum hsCRP were examined in all subjects. Results The serum hs-CRP in group of AF combined with cerebral embolism were obviously higher that in AF without cerebral embolism and the control group( P ＜ 0.01 ). Compared with AF without cerebral embolism group, the positive rate of hs-CRP( ＞ 5. 612 mg/L as positive criteria )in group of AF with cerebral embolism were different( P ＜0.01 ). Compared with AF without high level of hs-CRP,there was 11.32 times higher risk in AF with high level of hs-CRP. Conclusion The serum hs-CRP in patients with AF combined with cerebral embolism significantly raised, higher serum hs-CRP is a reliable predictor of AF combined with cerebral embolism.
展开▼
