Objective To detect the level of serum visfatin in overweight or obese young college students in China, and investigate the relationship between it and central aortic systolic blood pressure (CSBP).Methods The overweight or obese young college students (n=148 and aged from 17 to 23) were chosen from the central campus of Xi’an Technological University, and among them 45 students with hypertension were included in hypertension group and 103 with normal blood pressure (BP) were included in control group. CSBP was detected by using non-invasive SphygmoCor aortic pulse analyzer, and peripheral blood pressure was measured by using mercury sphygmomanometer. The level of serum visfatin was detected by using enzyme-linked immunosorbent assay (ELISA), and the relationship among visfatin, CSBP, peripheral brachial artery systolic pressure (BASP), peripheral brachial artery diastolic pressure (BADP) and brachial artery mean arterial pressure (BAMAP) was analyzed.Results CSBP, BASP, BADP and BAMAP were all higher in hypertension group than those in control group (allP<0.001). The level of serum visfatin was higher in hypertension group than that in control group [(227.33 ±30.93) μg/Lvs. (201.58±34.03) μg/L,P<0.001]. The level of serum visfatin was positively correlated to CSBP, BASP, BADP and BAMAP (r=0.498, 0.489, 0.414, 0.460, allP<0.001).Conclusion The hypertensive patients in overweight or obese young college students have higher level of serum visfatin compared with those with normal BP. The level of serum visfatin is positively correlated to CSBP and peripheral BP, which indicates that visfatin may participate the occurrence and development of obesity-related hypertension in young students.%目的：检测中国超重及肥胖青年大学生血清内脂素的水平，探讨血清内脂素水平与中心动脉收缩压的关系。方法从西安工业大学中央校区148例17~23岁的超重及肥胖青年大学生中筛选出高血压患者45例为高血压组，血压正常者103例为对照组。使用SphygmoCor无创主动脉脉搏分析仪测量中心动脉收缩压；测量外周血压；检测血清内脂素水平，并分析其与中心动脉收缩压、外周肱动脉收缩压、舒张压及平均动脉压的关系。结果高血压组的中心动脉收缩压、外周肱动脉收缩压、外周肱动脉舒张压、外周肱动脉平均动脉压均高于对照组，差异具有统计学意义（P均＜0.001）。高血压组血清内脂素水平较对照组高[（227.33±30.93）μg/Lvs.（201.58±34.03）μg/L]，差异具有统计学意义（P＜0.001）。血清内脂素水平与中心动脉收缩压、外周肱动脉收缩压、外周肱动脉舒张压、外周肱动脉平均压呈正相关，相关系数分别为0.498、0.489、0.414、0.460（P均＜0.001）。结论超重及肥胖青年大学生中高血压患者血清内脂素水平高于血压正常者，并且内脂素与中心动脉收缩压及外周血压呈正相关，预示内脂素可能参与青年大学生肥胖相关性高血压的发生及发展。
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