Objective To investigate the expression of breast cancer gene 1(BRCA-1) and CA 125 in endometrial carcinoma and predict the prognosis of patients.Methods 58 cases of endometrial cancer patients , 31 cases of atypical proliferative endometrium, and 13 cases of normal human endometrial tissue from the Dongguan People＇s Hospital from May 2011 to May 2013 were collected as group A,B and C.Immunohistochemical SP method was used to detect the expression of BRCA -1 and CA 125 in the three groups of endometrial tissues , and the expression differences of the above indicators and their effects on the prognosis of endometrial cancer were analyzed.Results ① The positive expression rates of BRCA -1 in A, B, and C groups were 32.8 %, 61.3 %, and 92.3 %, respectively, and the positive expression rates of CA 125 were 74.1%, 48.4%, and 0 respectively.②The positive expression of BRCA -1 was associated with FIGO stage, tissue differentiation and lymph node metastasis ( P＜0.05); The positive expression of CA 125 was associated with FIGO stage and tissue differentiation (P＜0.05).③The survival rate of BRCA -1 positive patients was higher than that of BRCA -1 negative patients (94.7 % vs 71.8 %, P＜0.05) .④ There was a negative correlation between BRCA -1 and CA 125 expression in endometrial carcinoma (P＜0.05).Conclusion The expression of BRCA-1 and CA 125 plays an important role in the occurrence and progression of endometrial cancer .The expression of BRCA -1 and CA 125 is negatively correlated.The clinical diagnosis of BRCA -1 and CA 125 can provide reference value for early diagnosis and judgment of patients＇condition and prognosis.%目的 探讨乳腺癌基因-1(breast cancer gene 1,BRCA-1)和CA 125在子宫内膜癌(endometrial cancer,EC)组织中的表达及对患者预后的预测作用分析.方法 收集2011年5月至2013年5月于东莞市人民医院诊治的58例EC患者(A组)、31例非典型增生型子宫内膜组织(B组)、13例来院体检的健康人正常子宫内膜组织(C组),采用免疫组织化学SP法检测子宫内膜组织中BRCA-1和CA 125的表达,分析上述指标的表达差异及其对EC预后的影响.结果 ① BRCA -1 在A、B、C 3 组中的阳性表达率分别为32.8 %、61.3 %、92.3 %,CA 125阳性表达率分别为74.1 %、48.4 %、0.②BRCA-1阳性表达与FIGO分期、组织分化及淋巴结转移有关(P＜0.05);CA 125阳性表达与FIGO分期及组织分化有关(P＜0.05).③ BRCA-1阳性表达患者的生存率(94.7 %)高于BRCA-1阴性表达患者(71.8 %),差异有统计学意义(P＜0.05).④BRCA-1与CA 125在EC中表达呈负相关性(P＜0.05).结论 BRCA-1与CA 125表达在EC的发生和进展过程中起重要作用,两者表达呈负相关,通过临床BRCA-1与CA 125检测可为早期诊断和判定EC患者病情、预测预后提供参考价值.
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