目的：探讨老年肺癌患者化疗期间抑郁相关危险因素，为临床实施针对性心理干预提供参考。方法选择2012年9月至2015年10月本院收治的253例老年肺癌患者为研究对象。通过抑郁量表（GDS）调查老年肺癌患者化疗期间抑郁的发生情况，对患者的临床资料进行单因素分析，采用Logistic回归分析老年肺癌患者化疗期间抑郁相关危险因素。结果253例老年肺癌患者化疗期间121例患者被诊断为抑郁，化疗期间抑郁发生率为47.83%；单因素分析显示，抑郁患者中了解病情、女性、高中以下文化水平、家庭月收入低于2750元、Ⅱ度及以上疼痛、曾行肺癌针对性手术治疗的患者比例均显著高于非抑郁患者（P＜0.05）；多因素非条件的Logistic回归分析显示，了解病情、女性、高中以下文化水平、家庭月收入低于2750元、Ⅱ度及以上疼痛为老年肺癌患者化疗期间发生抑郁的危险因素。结论在老年肺癌患者化疗期间应，临床医师根据其收入、性别、文化程度进行个体化干预，并积极降低患者癌痛程度，从而减少化疗期间抑郁的发生，改善患者预后。%Objective To explore the risk factors of depression in elderly patients with lung cancer during chemotherapy period, and to provide reference for clinical practice. Method From September 2012 to October 2015, 253 cases of elderly patients with lung cancer in our hospital were selected as research objects. Evaluated patients' symptoms of depression during chemotherapy period by Geriatric Depression Scale (GDS). The clinical data of patients were analyzed by single factor analysis, and used Logistic regression analysis to analyze the risk factors of depression in elderly patients with lung cancer during chemotherapy period. Result 121 patients were diagnosed as depression in 253 cases, the incidence rate of depression was 47.83%;the single factor analysis showed that the rates of patients who understood their illness, female, education level lower than high school, family monthly income less than 2750 yuan, underⅡdegrees or more serious pain, treated with a specific aim of surgical treatment of lung cancer in depressed patients were significantly higher than non-depressed patients (P<0.05);Logistic regression analysis of multiple factors showed that the high understanding level of illness, female, education level lower than high school, the family monthly income less than 2750 yuan, Ⅱdegree or more serious pain were the risk factors for depression in elderly patients with lung cancer during chemotherapy period. Conclusion Elderly lung cancer patients during chemotherapy period should be individualized according to the patient intervention of income, gender, education level, and actively reduce the degree of cancer pain, reduce the incidence of depression during chemotherapy period, improve prognosis.
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