ObjectiveTo study the clinical effect observation of antibiotic de-escalation therapy for children with severe pneumonia.MethodFrom January 2013 to January 2014, 78 children with severe pneumonia were selected as the research objects, they were randomly divided into observation group and control group, 39 cases in each group. All the children were treated with basic therapy, control group children were treated with conventional antibiotics, observation group children were given antibiotic de-escalation therapy. The clinical efifcacy, time of antibiotic use and the length of hospital stay between the two groups were compared. ResultThe total effective rate of observation group was signiifcantly higher than control group, the length of hospital stay and the time of antibiotic use were signiifcantly less than control group (P<0.05).Conclusion The application of antibiotic de-escalation therapy for children with severe pneumonia is effective, can signiifcantly reduce the overall dosage of antibiotics, and promote the recovery of children as soon as possible, has important clinical application value.%目的：研究抗生素降阶梯治疗小儿重症肺炎的临床效果。方法选取本院2013年1月至2014年1月收治的重症肺炎患儿78例为研究对象，将其随机分为观察组与对照组，每组各39例。所有患儿均给予基础治疗，同时，对照组患儿应用常规抗生素治疗，观察组患儿应用抗生素降阶梯治疗。比较两组患儿临床疗效、抗生素使用时间及住院时间。结果观察组患儿治疗总有效率显著高于对照组（P＜0.05），住院时间及抗生素使用时间均显著少于对照组（P＜0.05）。结论抗生素降阶梯治疗对小儿重症肺炎的疗效确切，可显著减少抗生素整体用量，同时促进患儿尽快恢复，具有重要的临床应用价值。
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