Crohn’s disease( CD)is a gastrointestinal progressive granulomatous disease with unknown etiology. It is characterized as active stage alternating with remission stage,long-term course with many complications,sometimes needing surgery and having the tendency of relapse in patient ’s whole life. Therefore,it is important to define an effective therapeutic endpoint to ameliorate the natural course of CD. This article reviewed the progress in defining treatment endpoint of CD.%克罗恩病（ CD）是一种原因不明的胃肠道进行性肉芽肿性疾病，活动期与缓解期交替，病程长，并发症多，有时需接受外科手术，并有终生复发倾向。因此，在临床上制定有效的治疗终点，从而改善CD的自然病程至关重要。本文就CD治疗目标的研究进展作一综述。
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