目的:探究口服地屈孕酮辅助下IVF-ET妊娠结局影响.方法:回顾性分析2014年3月至2015年3月160例在我院进行IVF-ET的不孕患者的临床资料,依照取卵后不同的黄体支持方法将患者分为观察组、对照组,每组80名患者,对照组患者采用肌肉注射黄体酮针剂进行黄体支持治疗,观察组采用口服地屈孕酮片进行黄体支持治疗.比较两组患者妊娠结局及用药后产生的不良反应情况.结果:两组在进行体外受精-胚胎移植时,移植胚胎评分、胚胎个数及入组患者子宫内膜厚度比较无统计学意义(P＞0.05).观察组临床妊娠率为53.75％,对照组临床妊娠率为46.25％,观察组患者临床妊娠例数及分娩婴儿数高于对照组,但比较无统计学意义(P＞0.05);两组患者异位妊娠及流产发生率比较无统计学意义(P＞0.05).观察组用药后不良反应发生率为8.75％,对照组用药后不良反应发生临床为21.25％,观察组患者用药后不良反应发生率明显低于对照组,比较具有统计学意义(P＜0.05).结论:不孕患者在进行IVF-ET时,口服地屈孕酮片与肌注黄体酮进行黄体支持治疗所获得的妊娠结局是相似的,但口服地屈孕酮治疗时,患者药物不良反应发生率较低,因此,临床医师可考虑将口服地屈孕酮代替黄体酮针剂进行黄体支持治疗.%Objectives:To explore the effect of oral dydrogesterone on pregnancy outcome of in vitro fertilization embryo transfer (IVF-ET).Methods:160 infertile patients in our hospital for IVF-ET from March 2014 to March 2015 were selected.According to the different luteal support after oocyte retrieval methods,they were divided into observation group and control group,with 80 patients in each group.The control group was treated by intramuscular injection of progesterone for luteal support treatment,and observation group was treated with oral administration of dydrogesterone tablets luteal support.The pregnancy outcome and adverse drug reactions were compared between the two groups.Results:There was no significant difference between the two groups during IVF-ET in embryo score,number of embryos and endometrial thickness of the patients (P ＞ 0.05).The clinical pregnancy rate of observation group was 53.75％ and the clinical pregnancy rate in control group was 46.25％.The clinical pregnancy cases and baby number in observation group were higher than these in control group,but the difference was not statistically significant (P ＞ 0.05).Difference in ectopic pregnancy and abortion rate between the two groups was not significant (P＞ 0.05).The incidence of adverse reaction in observation group and control group after treatment was 8.75％ and 21.25％ respectively,with statistically significant difference (P ＜ 0.05).Conclusion:For infertile patients undergoing IVF-ET,oral dydrogesterone tablets and intramuscular injection of progesterone as luteal support treatment of pregnancy obtained is consistent,but the incidence of adverse reactions in oral dydrogesterone treatment is low.Therefore,clinicians may consider oral dydrogesterone instead of progesterone injection for luteal support.
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