目的:研究早期梅毒患者血清IL-27、IL-33水平.方法:以我院2014年1月至2015年1月期间接诊的80例早期梅毒患者作为研究对象,根据其治疗效果将其分为梅毒血清转阴组和梅毒治疗无效组两组,每组各40人,然后再选择40例正常人群作为对照组.在治疗前,对三组患者的血清RPR滴度进行检测;在治疗前后,分别对三组患者的血清IL-27和血清IL-33水平进行检测,比较其在治疗前后的不同以及各组患者之间的差异,并对其结果进行分析.结果:治疗前,梅毒血清转阴组以及梅毒治疗无效组的血清RPR滴度均没有明显的差异(P＞0.05),具有可比性.治疗前,三组患者的血清IL-27水平具有明显的差异(P＜0.05);治疗后,梅毒血清转阴组患者以及正常对照组患者的血清IL-27水平与治疗前比较,没有明显的变化(P＞0.05),而梅毒治疗无效组患者的IL-27水平变化明显(P＜0.05);治疗前,梅毒血清转阴组和梅毒治疗无效组两组患者的血清IL-33水平没有明显的差异(P＞0.05),而两组患者的血清IL-33水平均明显高于正常对照组(P＜0.05);治疗后,梅毒治疗无效组患者以及正常对照组患者的血清IL-33水平与治疗前比较,没有明显的变化,差异无统计学意义(P＞0.05),而梅毒血清转阴组患者的IL-33水平变化明显.结论:在患者的血清中,IL-27及IL-33均参与患者机体对梅毒螺旋体的免疫应答,其中IL-27水平对于机体清除梅毒螺旋体具有更加重要的意义,对于早期的梅毒患者,在患者体内有较高水平的IL-27,则其血清RPR转阴可能性更大,具有临床应用价值,值得推广.%Objectives:To study the serum IL-27 and IL-33 levels of patients with early syphilis.Methods:80 early syphilis patients in our hospital from January 2014 to January 2015 were selected as the research objects.According to the treatment effect,they were divided into effective group and ineffective group,with 40 cases in each group,and then 40 normal people were selected as the control group.The titer of RPR of the three groups before treatment were detected and compared.Serum IL-27 and IL-33 levels in three groups before and after treatment were respectively detected and the results were analyzed.Results:Before treatment,serum RPR titer effective group and ineffective group had no significant difference (P ＞ 0.05).Before treatment,serum IL-27 levels in three groups had statistically significant difference (P ＜ 0.05).After treatment,serum IL-27 levels of effective group and control group had no significantly change and the difference was not statistically significant (P ＞ 0.05).Serum IL-27 level of ineffective group significantly changed,with statistical significance (P ＜ 0.05).Before treatment,serum IL-33 levels of effective group and ineffective group had no obvious difference (P ＞ 0.05),and serum IL-33 levels of effective group and ineffective group were significantly higher than that in control group,with statistical significance (P ＜ 0.05).After treatment,serum IL-33 levels of ineffective group and control group had no significantly change and the difference was not statistically significant (P ＞ 0.05).IL-33 levels of effective group significantly changed with statistical significance (P ＜ 0.05).Conclusion:Serum IL-27 and IL-33 are both involved in the immune response of Treponema pallidum.The IL-27 level has more important significance for clearing Treponema pallidum.For patients with early syphilis,the higher level of IL-27 in patients is,the more likely the serum RPR turns negative.
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