Objectives:To observe the efficacy and safety of benzathine penicillin combined with cefatrizine in the treatment of patients with syphilis.Methods:82 patients with syphilis in our hospital from January 2014 to November 2015 were studied.In accordance with the random number table method,they were divided into observation group and control group,41 cases in each group.Control group was treated with benzathine penicillin and observation group was treated with benzathine penicillin combined with cefatrizine.Treatment effect of the two groups before and after treatment was compared.The peripheral blood Th cell subsets and the adverse reaction of two groups were compared.After 3 months follow-up,the treatment results of the last follow-up were compared.Results:In observation group,the cure rate was 70.73％ and the total efficiency was 97.56％,which were significantly higher than these in control group (46.34％ and 82.93％) (P ＜ 0.05).At the end of the follow-up,the RPR negative ratio of observation group was 94.87％,which was significantly higher than that in control group (78.95％) (P ＜0.05).Th1 and Th1/Th2 of the two groups after treatment were higher than these before treatment (P ＜ 0.05).Th1 and Th1/Th2 of observation group after treatment were higher than these in control group (P ＜ 0.05).The adverse reaction rate of observation group had no significant difference with that of control group (P ＞ 0.05).Conclusion:Benzathine penicillin combined with cefatrizine in the treatment of syphilis has good curative effects and safety,and also can effectively improve the immune function of patients,thusly worthy of promotion.%目的:观察苄星青霉素联合头孢三嗪对梅毒患者的疗效及安全性影响.方法:选择自2014年1月至2015年11月在医院诊治的梅毒患者82例进行研究,依照随机数字表法将患者划分成观察组以及对照组各41例,对照组单纯予以苄星青霉素治疗,观察组在此基础上另予以头孢三嗪治疗,对比两组疗效,治疗前后的外周血Th细胞亚群,以及不良反应.随访3个月,比较末次随访的治疗结果.结果:观察组治愈率是70.73％,总有效率是97.56％,分别较对照组的46.34％及82.93％明显更高(P＜0.05).观察组末次随访的RPR阴性比例为94.87％,显著高于对照组的78.95％ (P ＜0.05).两组治疗后的Th1及Th1/Th2均分别高于各自治疗前(P＜0.05).观察组治疗后的Th1及Th1/Th2均分别高于对照组治疗后(P＜0.05).观察组皮疹和恶心、呕吐,以及腹泻的不良反应发生率与对照组相比,差异不含统计学意义(P＞ 0.05).结论:苄星青霉素联合头孢三嗪治疗梅毒患者,可产生较好的疗效及安全性,还可有效改善患者的机体免疫功能,效果明显,值得给予推广.
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