目的：探讨法舒地尔联合α－硫辛酸治疗2型糖尿病性勃起功能障碍（DMED）的临床价值。方法：连续选择2013年6月至2014年4月入我院内分泌科诊断为 DMED 患者共76例，平均年龄（46.7±7.2）岁，平均糖尿病病程（6.2±2.8）年，平均体质量指数（25.4±1.3）kg／m2。将其随机分入观察组40例和对照组36例，均予血糖控制治疗。观察组给予盐酸法舒地尔60mg、α－硫辛酸600mg 分别加入250mL 生理盐水中静滴，1次／d，疗程4周；对照组给予他达拉非5mg 口服，1次／晚，4至6周为1个疗程。结果：研究无脱落病例，观察组治疗有效率明显高于对照组（95.0％ vs．80.5％，P ＜0.05）；治疗后观察组 IIEF －5、EHGS评分及肱动脉 FMD 值均显著高于对照组（P ＜0.05）；观察组不良反应发生率明显低于对照组（7.5％ vs．13.9％，P ＜0.05）。结论：法舒地尔联合α－硫辛酸可通过改善 DMED 患者血管内皮功能、勃起硬度达到治疗勃起障碍的目的，且少不良反应，安全性好。%Objectives:To study the effect of Fasudil combined with alpha lipoic acid in treatment of type 2 diabetes patients with impotence.Methods:A total of 76 patients diagnosed as type -2 diabetes with impotence from June 2013 to April 2014 in our hospital were selected.The mean age was (46.7 ±7.2)years;the mean dia-betes course was (6.2 ±2.8)years and the mean body mass index was (25.4 ±1.3)kg/m2 .The 76 patients were divided randomly into experiment group (n =40)and control group (n =36),all receiving glucose control.The pa-tients in experiment group received Fasudil 60mg and alpha lipoic acid 600mg +250mL NS once per day,for 4 weeks.The patients in control group received Tadalafil 5mg.Results:There was no loss of cases.the total efficacy rate in experiment group was significantly higher than that in control group (95.0% vs.80.5%,P <0.05);the IIEF -5,EHGS score and brachial artery FMD value in experiment group were significantly higher than these incontrol group (P <0.05);the incidence of complications in experiment group was significantly less than that of con-trol group (7.5% vs.13.9%,P <0.05).Conclusion:Fasudil combined with alpha lipoic acid can greatly im-prove the treatment effect of patients with type 2 diabetes and impotence.
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