Objectives:To investigate the value of thinprep cytology test combined with HPV test in cervical cancer screening.Method:5,586 women were screened for cervical cancer with the method of thinprep cytology test,HPV test and the combined 2 tests.The colposcopic biopsy results were compared.Results:There were 41 1 cases of ASCUS (7.36%),105 cases of LSIL (1.88%),67 cases of HSIL (1.20%)and 10 cases of SCC (0.18%).The results of the HPV test showed that there were 890 positive cases.Moreover,with the level of cer-vical lesions graded,high-risk HPV infection increased as well (P<0.05 ).Thinprep cytology test combined with HPV test could significantly improve the specificity and positive predictive check value,as well as reduce the false positive rate.In addition,HPV test followed by cytology test had high specificity and positive predictive value,with low false positive rate and false negative rate than the initial cytology test followed by HPV test.Conclusion:HPV test followed by cytology test has higher specificity for cervical cancer.%目的：探讨宫颈液基薄层细胞检测联合HPV检查在宫颈癌筛查中的应用价值。方法：应用宫颈液基薄层细胞检测和HPV检查以及两种方法的联用，对5586名妇女进行宫颈癌筛查，并与阴道镜活检的结果进行比对。结果：细胞学检查结果显示，ASCUS 411例（占7.36％），LSIL 105例（占1.88％），HSIL 67例（1.20％），SCC 10例（0.18％）。而单用HPV检查，发现阳性患者890例，且随着宫颈病变级别升高，高危型HPV感染率增加（P＜0.05）。宫颈液基细胞学检查联用HPV检查与两种方法单独应用相比能明显提高检查的特异性和阳性预测值，并能降低假阳性率。与此同时，先进行HPV检查，后进行细胞学检查的方案，具有较高的特异性和阳性预测值，同时假阳性率和假阴性率较低，明显优于先进行细胞学检查，后进行HPV检查的方案。结论：先进行HPV检查，后进行细胞学检查的方案对宫颈癌的筛查准确性高，不失为一种先进的宫颈癌筛查方法。
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