目的：探讨比较盐酸坦洛新缓释片的不同给药方案治疗早泄的临床效果。方法：选取2010年8月至2013年8月于我院进行治疗的243例早泄患者为研究对象，根据给药方案的不同将其随机分为0.2mg qd组、0.2mg bid组、0.4mg qd组，每组81例。将3组患者治疗前后对夫妻性生活的满意程度、阴道内射精潜伏期、CIPE评分进行统计比较。结果：3组患者治疗前的阴道内射精潜伏期分别为（0.71±0.23） min、（0.67±0.24）min、（0.69±0.19）min，P＞0.05，无统计学差异；治疗3个月后分别为（2.45±0.56）、（2.61±0.62）和（3.71±0.43）min，结果显示0.2mg qd组和0.2mg bid组差异无显著差异，0.4mg qd组与以上两组有显著的统计学差异（P＜0.05）。治疗后3组患者夫妻性生活满意度从高到低依次为：0.4mg qd组、0.2mg bid组、0.2mg qd组。治疗前3组患者CIPE 评分结果分别为（29.5±4.3）、（28.9±3.8）、（29.2±3.6）分，无统计学差异；治疗后分别为（32.2±3.1）、（35.9±3.1）、（37.5±3.7）分，其中0.4mg qd组与其他两组比CIPE评分结果明显增高，有统计学差异（P＜0.05）。结论：盐酸坦洛新缓释片的不同给药方案用于治疗早泄有不同的临床效果，1次/d给予0.4mg有更显著的临床治疗效果。%To observe and compare the clinical effect of different administrations of tamsulosin hydrochloride sustained release tablets in treating premature ejaculation.Methods:243 patients with premature e-jaculation treated in our hospital from August 2010 to August 2013 were selected as research objects and divided into three groups randomly,0.2mg qd group,0.2mgbid group and 0.4mg qd group,each group for 81 patients.The satisfactory degree of married couple sex life,intravaginal ejaculatory latency time and CIPE score before and after treatment of three groups were compared.Results:The intravaginal ejaculatory latency time of three groups before treatment were (0.71 ±0.23)min,(0.67 ±0.24)min and (0.69 ±0.19)min,P>0.05,which had no statistical significance,and that 3 months after treatment were (2.45 ±0.56),(2.61 ±0.62)and (3.71 ±0.43)min.The result indicated that there was no evident difference between 0.2mg qd group and 0.2mg bid group,and there was evident statistical significance between 0.4mg qd group and the other two groups(P<0.05 ).The satisfactory de-gree of married couple sex life of three groups after treatment in order was 0.4mg qd group,0.2mg bid group and 0.2mg qd group.CIPE score of three groups before treatment was (29.5 ±4.3),(28.9 ±3.8)and (29.2 ±3.6) respectively,which had no statistical significance,and that after treatment was (32.2 ±3.1 ),(35.9 ±3.1 )and (37.5 ±3.7),in which 0.4mg qd group increased evidently compared with that of the other two groups,which had statistical significance(P<0.05 ).Conclusion:Different administrations of tamsulosin hydrochloride sustained re-lease tablets have different clinical effect in treating premature ejaculation,and giving 0.4mg once everyday has more evident clinical treatment effect.
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