目的：回顾本地区男性泌尿生殖道患者感染解脲支原体（UU）、人型支原体（MH）的分布状况，了解支原体对12种抗生素体外药物敏感试验的现状。方法：对1599例男性泌尿生殖道感染患者前列腺液标本进行支原体（Uu、MH）培养及药敏试验。结果：1599例检测标本中，总感染率为23.08％，单纯UU阳性277例（75.07％），UU －Mh 阳性81例（21.95％），单纯 Mh 阳性11例（2.98％）。MH 对强力霉素（DOX）、交沙霉素（JOS）、美满霉素（MIN）全部敏感，UU 对JOS、MIN、DOX、环酯红霉素（ECC）、克拉霉素（CLA）均非常敏感，UU－MH混合感染的耐药率明显高于单纯UU或MH感染。结论：临床治疗支原体感染时应尽量根据药敏结果选择敏感药物，DOX、MIN和JOS可作为本地区临床经验用药的首选药物。%Objectives:To review the incidences of urogenital tract infection caused by ureaplasma urealyti-cum (UU)and mycoplasma hominis (MH)and their susceptibilities to 12 antibiotic agents.Methods:UU and MH were cultured and their drug susceptibilities from 1 ,599 patients with urogenital tract infections were statistically analyzed.Results:The overall positive incidence of gential mycoplasmas was 23.08%.The most common pattern was UU mono-infection (75.07%);the UU-MH co-infection pattern ranked second (21.95%)and MH mono-infection was lowest (2.98%).However,a significantly higher infection rate by genital mycoplasmas was found in young men (age range:21 -50 years).Overall,MH complete susceptibility to doxycycline (DOX),josamycin (JOS)and minocycline (MIN),while UU had high susceptibility rates to JOS,MIN,DOX,erythromycin cyclocar-bonate (ECC)and clarithromycin (CLA).The resistance rates of UU-MH-mixed isolates to most of drugs were significantly higher than those of UU-or MH-single isolates.Conclusions:The laboratory screening and antimi-crobial susceptibility testing for genital mycoplasmas is vital to treat the infection.According to the empirical treat-ment of mycoplasma infection,DOX,MIN,and JOS can be taken as the drugs of first choice.
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