Objectives:To explore the clinical and pathological characteristics of vulvar disease and to provide guidance for clinical diagnosis and treatment.Methods:The clinical and histopathologic data of 250 biopsies of vulvar disease were analyzed.Results:Among all these 250 cases,12.8％ suggests infectious diseases,46％ demonstrates cystic and tumor-like lesions,12.4％ shows hyperplastic or atrophic diseases,24.4％ shows benign tumors and 4.4％ shows malignant tumors.Infectious disease occurs most frequently in the group of 18 to 35 years old women.The hyperplastic or atrophic lesion and malignant tumors of the vulva more often occurs in the group of women elder than 50 years.All differences are statistically significant (P ＜0.001).Conclusions:There are many types of vulvar diseases.Benign tumors and tumor-like lesions and cystic lesions are easily detected by biopsy.Young and middle-aged women should pay attention to prevent infectious diseases and tumor-like lesions while old women should be alert to the risk of incidence of hyperplastic or atrophic diseases and squamous cell carcinoma.Biopsy is helpful for diagnosis of vulvar disease and avoidance of misdiagnosis.Dermatologist particularly should attach more importance to lesion biopsy in diagnosis of vulva disease.%目的:分析外阴疾病活检的临床与病理特点,提高对外阴疾病的认识,指导临床与治疗.方法:回顾性分析250例女性外阴活检的临床及病理资料,进行分析.结果:250例患者中12.8％病例为感染性疾病,46％为囊肿性病变及瘤样病变,12.4％为增生或萎缩性疾病,24.4％为良性肿瘤,4.4％为恶性肿瘤.感染性疾病以18至35岁组发生率最高,外阴增生或萎缩性病变及恶性肿瘤以≥50岁组常见,差异均有极显著性意义(P＜0.001).结论:外阴疾病种类较多,囊肿性病变、瘤样病变及良性肿瘤活检率高.中青年女性注意预防感染性疾病及瘤样病变,老年女性应警惕具有癌变风险的增生或萎缩性疾病及鳞癌的发生.活检有助于明确诊断,避免误诊的发生.皮肤科医生尤其应重视外阴病变活检.
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