Objective To explore the effects of MDR1 C3435T on the peripheral white blood cell counts in workers exposed to benzene. Methods One hundred and twenty-one benzene-exposed workers and 110 healthy controls without benzene exposure were enrolled in this study. White blood cell counts influenced by the polymorphism of MDR1 gene were analyzed. Results The frequency of MDR1 3435 C/C, C/T, T/T in healthy controls was 37.27%, 46.36%, 16.37%, respectively,and it was 38.84%, 41.33%, 19.83% in the benzene-exposed workers, respectively. The frequency of the MDR1 gene was also not significantly different between benzene exposed workers and controls. Subjects exposed to benzene with MDR1 3435 mutation genotype (T/T) had the significantly lower WBC[(5.46±1.51 )×109/L] than those carrying wild type(C/C) and heterozygous (C/T), whose WBC were (6.08±1.28)×109/L(P=0.044). Conclusion P-glycoprotein encoded by MDR1 gene may be implicated into the hematotoxicity of benzene. Subjects carrying MDR1 3435 T/T genotype may have a higher risk of benzene poisoning.%目的 探讨MDR1 C3435T对苯作业人员外周血白细胞(WBC)计数的影响.方法 检测121例苯作业人员和110例正常对照组MDR1基因的多态性,并对苯作业人员中携带不同基因型个体的WBC计数进行比较.结果 对照组MDR1 3435 C/C基因型分布频率为37.27%,C/T基因型为46.36%,T/T基因型为16.37%;接触组C/C基因型分布频率为38.84%,C/T基因型为41.33%,T/T基因型为19.83%,两组比较,差异无统计学意义(P=0.686).接触组携带T/T基因型者WBC计数为(5.46±1.51)×109/L,明显低于携带C/C+C/T基因型者[WBC计数为(6.08±1.28)×109/L],差异有统计学意义(P=0.044).结论 苯血液系统毒作用机制中可能涉及多药耐药基因编码产物P-糖蛋白的参与,携带MDR1 3435T/T基因型个体接触苯,可增高中毒风险.
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