目的：了解2011—2013年某院鲍曼不动杆菌的临床分布与耐药性变化趋势，为指导临床合理使用抗菌药物提供依据。方法对该院2011年1月—2013年12月分离的鲍曼不动杆菌来源和药敏试验结果进行统计分析。结果2011—2013年共分离细菌14705株，其中鲍曼不动杆菌1999株（13．59％），3年鲍曼不动杆菌分别占分离病原菌的12．74％、13．05％、14．85％，呈逐年上升趋势（χ2＝9．458，P ＝0．002）。标本来源主要为痰（1541株，77．09％），分离科室以呼吸内科、外科重症监护室（SICU）和急诊重症监护室（EICU）为主，分别占21．71％、16．26％和8．26％。鲍曼不动杆菌对各类抗菌药物的耐药率均逐年升高（均 P ＜0．05）；多重耐药和泛耐药鲍曼不动杆菌分离率亦呈逐年上升趋势（均 P ＜0．001），差异有统计学意义。结论医院鲍曼不动杆菌的分离率及耐药率均逐年上升，多重耐药及泛耐药现象较明显，临床科室应引起重视。%Objective To investigate the clinical distribution and change in antimicrobial resistance of Acinetobact-er baumannii (A.baumannii)from a hospital between 2011 and 2013,so as to provide guidance for clinical treat-ment.Methods Sources and antimicrobial susceptibility testing results of A.baumannii from a hospital were ana-lyzed statistically.Results A total of 14 705 bacterial isolates were isolated in 2011 —2013,13.59%(n=1 999)of which were A.baumannii isolates,the percentage of A.baumannii in isolated pathogens in 3 years was 12.74%, 13.05%,and 14.85% respectively,which showed a rising trend (χ2 =9.458,P =0.002).The main specimen was sputum (n = 1 541 ,77.09%),bacteria were mainly isolated from patients in respiratory disease department (21 .71 %),surgical intensive care unit (16.26%),and emergency intensive care unit (8.26%).Antimicrobial re-sistance rates of A.baumannii increased year by year(all P <0.05);multidrug-resistant and extensively drug-resist-ant A.baumannii also increased year by year (all P <0.001).Conclusion Isolation rate and antimicrobial resistance rate of A.baumannii strains increase year by year,multidrug-resistant and extensively drug-resistant A.baumannii strains are obvious,which should be paid more attention in clinical department.
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