Objective To analyze the rules of acupoint selection in treating knee osteoarthritis with acupuncture and moxibustion therapy based on data mining; To provide references for clinical treatment.MethodsArticles about treating knee osteoarthritis with acupuncture and moxibustion were retrived from China National Knowledge Infrastructure (CNKI), Wanfang academic periodical full-text database, Chinese Journal Full-text Database (VIP) and SinoMed in China from Jan. 1st 2006 to Jan. 1st 2016. The database of acupuncture and moxibustion prescription was set up. The Apriori association rules, system cluster analysis and factor analysis were adopted in order to analyze the rules of acupoint selection for knee osteoarthritis.ResultsTotally 190 articles were included, covering 228 acupuncture- moxibustion prescriptions, 65 acupoints and the total frequency for 1736 times. The usual acupoints in the lower limbs were Dubi (ST35), Neixiyan (EX-LE 4), and Yanglingquan (GB34). The main maridians were Stomach Meridian of Foot-Yangming, Spleen Meridian of Foot-Taiyin, and Gallbladder Meridian of Foot-Shaoyang, accounting to for 1626 times (93.66%). Cluster analysis achieved other four groups of acupoint selection based on syndrome differentiation.ConclusionLocal acupoints and dialectical point selection were important principle in treating knee osteoarthritis combined with acupoint selection based on syndrome differentiation.%目的：运用数据挖掘技术分析针灸治疗膝关节骨性关节炎的取穴规律，为临床治疗提供参考。方法计算机检索中国知识资源总库（CNKI）、中国学术期刊数据库（万方数据）、中文科技期刊数据库（重庆维普）、中国生物医学文献服务系统（SinoMed）2006年1月1日－2016年1月1日针灸治疗膝关节骨性关节炎的临床研究文献，建立相应数据库，采用Apriori关联规则、系统聚类、因子分析等多元统计方法分析取穴规律。结果共纳入文献190篇，涉及针灸处方228首、腧穴65个，取穴总频次1736次。常取穴位有犊鼻、内膝眼、阳陵泉等，以足阳明胃经、足太阴脾经、足少阳胆经为主。主要取穴部位为下肢部，达1626频次（93.66%）。系统聚类分析得到除主穴外的辨证配穴有4组。结论针灸治疗膝关节骨性关节炎以局部取穴为基础，结合辨证配穴。
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