Objective To observe the effect of Xiaoxianxiong Decoction combined with metformin on glucose and lipid metabolism of phlegm-heat type 2 diabetic patients (T2DM). Methods Totally 104 phlegm-heat T2DM patients were randomly divided into two groups (each contains 52 cases), and given the diabetes lifestyle intervention. Control group additionally took 0.5 g metformin twice daily. And treatment group, besides taking 0.5 g metformin, was given Xiaoxianxiong Decoction, one dose and three times per day warmly. After 12 weeks, FBG, HbA1C, TC, TG, HDL-C, LDL-C, 2 hPG of the two groups were determined, and the therapeutic effect was evaluated. Results The total effective rate in the treatment group was 92.31%, and 76.92%in control group (P<0.01). The difference in symptom score, FBG, 2 hPG, TC, TG, HDL-C and LDL-C between the two group were significant, so as that between before and after treatment of both groups (P<0.05). Conclusion Xiaoxianxiong Decoction combined with metformin can effectively lower the levels of blood glucose and blood lipid in phlegm-heat T2DM patients, enhance the therapeutic effect and improve the metabolism of glucose and lipid.%目的：观察小陷胸汤联合盐酸二甲双胍片对2型糖尿病(T2DM)痰湿蕴热型患者糖脂代谢的影响。方法104例T2DM痰湿蕴热型患者按随机数字表法分为2组,每组52例。2组均行糖尿病生活方式干预。对照组用盐酸二甲双胍片0.5 g,每日2次口服；观察组在对照组基础上加用小陷胸汤,每日1剂,分3次温服。治疗12周。2组患者均于治疗前后检测空服血糖(FBG)、糖化血红蛋白(HbA1C)、餐后2 h血糖(2 hPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并进行疗效评定。结果临床疗效总有效率观察组为92.31%(48/52),对照组为76.92%(40/52),观察组优于对照组(P＜0.01)。症状积分及FBG、2 hPG、TC、TG、HDL-C、LDL-C水平治疗前后及治疗后2组比较差异均有统计学意义(P＜0.05)。结论小陷胸汤与盐酸二甲双胍片合用能有效降低T2DM痰湿蕴热型患者血糖、血脂水平,可明显提高疗效,改善糖脂代谢。
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