Objective To observe the therapeutic effect of Danshen Ruangan Yin on hepatic fibrosis rats induced by CCl4 and its influence on renin-angiotensin-aldosterone system (RAAS), and to explore the antihepatofibrotic mechanism of Danshen Ruangan Yin. Methods Except 10 rats of normal control, other rats were induced by hypodermic injecting 40％ CCl4-olive oil mixture for 6 weeks to duplicate liver fibrosis,and then administrated with drugs based on groups (model, Enalapril, Danshen Ruangan Yin high,middle and low dosage) for 5 weeks. Serum ALB, ALT, AST, SOD, MDA, ACE, PRA, AngⅡ and ALD were detected. Results Danshen Ruangan Yin could decrease activity of ALT and AST, increase content of ALB,raise activity of SOD and depress content of MDA. Compared with model group, Danshen Ruangan Yin could decrease ACE, ALD and Ang Ⅱ significantly as well as increase PRA. Conclusion Danshen Ruangan Yin can improve liver function of hepatic fibrosis rats induced by CCl4 and inhibit plasma RAAS.%目的 观察丹参软肝饮对四氯化碳肝纤维化大鼠的治疗作用及其对血浆中肾素-血管紧张素-醛固酮系统(RAAS)的影响,探讨其抗肝纤维化的作用机制.方法 除10只大鼠作为正常组外,其余用40%四氯化碳橄榄油皮下注射诱导肝纤维化模型,持续5周.分成模型组、依那普利组及丹参软肝饮高、中、低剂量组,给予相应的药物5周后,测定血清白蛋白(ALB)、谷氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、超氧化物歧化酶(SOD)、丙二醛(MDA)以及RAAS指标血管紧张素转化酶(ACE)、血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD).结果 丹参软肝饮能够降低纤维化大鼠ALT,AST活性,提高ALB含量,升高SOD活性,降低MDA含量.与模型组比较,丹参软肝饮能显著降低ACE活性,降低ALD和AngⅡ水平,升高PRA.结论 丹参软肝饮能改善四氯化碳肝纤维化大鼠的肝功能,并对其血浆中RAAS有一定的抑制作用.
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