目的 通过肥大细胞(MC)与五羟色胺(5-HT)在肠易激综合征(IBS)大鼠肠道组织的表达改变,探讨九香止泻片的作用机制.方法 选用40只SD大鼠,随机分为空白组、模型组、实验组、对照组,每组10只.除空白组外,其余各组均予以胃湿热方法造模,同时再予以IBS慢性应激造模.造模至第22日开始,实验组予以九香止泻片灌胃,原药材量12.27 g/(kg·d);对照组予盐酸洛哌丁胺灌胃1.08 mg/(kg·d),每日1次,连续灌胃7 d.实验结束时观察各组大鼠肠道中MC与5-HT的表达等改变.结果 实验组在抑制湿热泄泻型IBS大鼠肠道中MC与5-HT表达等方面与模型组比较,差异有统计学意义(P＜0.05).结论 九香止泻片能够抑制湿热泄泻型IBS模型大鼠肠道(回盲部,结肠远端)中的5-HT及Mc的异常表达,从而达到止泻的目的.%Objective To explore the mechanism of Nine Enteric tablets by observing the mast cells and 5-HT expression of irritable bowel syndrome (IBS) rats. Methods Forty SD rats were divided into four groups: blank group, model group, experimental group, control group, 10 in each group. Except for the blank group, other groups were made for stomach damp-heat, and then for IBS with chronic stress. The experimental group was administrated with Nine Enteric tablets 12.27 g/(kg ·d) and the control group with loperamide hydrochloride 1.08 mg/(kg· d) once per day for 7 d. The intestinal mast cells and 5-HT expression were observed. Result Experimental group inhibited intestinal mast cells and 5-HT expression of damp-heat diarrhea type IBS rats compared with model group, the difference was significant (P ＜0.05).Conclusion Nine Enteric tablets can inhibit abnormal expression of intestinal (ileocecal, colon distal) mast cells and 5-HT of damp-heat diarrhea type IBS rat model, and thus achieve the purpose of relieving diarrhea.
展开▼
机译：分离的核酸（多核苷酸），反义寡核苷酸，抑制或减少编码CO2SEN蛋白的消息和/或CO2SEN蛋白或植物多聚核苷酸和多肽多糖的植物植株的表达的方法植物保护细胞，植物细胞，植物片，植物组织或植物，植物的一部分的碳吸收量和碳排量的负，正调节及增加，碳保护层和水流以及CO 2 / CO 2交换水交换或损失水开放植物，关闭植物的气孔，部分植物，器官，植物片或植物细胞，以增强或优化植物，植物片，器官，植物，植物的一部分上的生物量积累，植物，种子或植物细胞中的植物细胞或种子，板温度的降低和蒸腾强度的提高，降低了T型保护细胞中的效率降低和碳含量
