采用后合成修饰技术(postsynthetic modification,PSM)设计并合成手性金属-有机框架化合物(metal-organic frameworks,MOFs),将L型脯氨酸衍生物Boc-L-ProCl,后修饰到金属有机-框架化合物Cr-MIL-101-NH2孔道中,制得手性金属有机-框架化合物Cr-MIL-101-PaB2.经核磁(1H NMR)结果证实,修饰产率高达64％,固体圆二色谱(CD)测试结果表明经后合成修饰后的Cr-MIL-101-PaB2具有旋光性.红外光谱(IR)、氮气脱附-吸附、热重(TGA)、粉末X射线衍射(PXRD)手段对其进行表征.实验结果证实,为避免金属-有机框架化合物自组装的不确定性,采用后合成修饰技术,可按需合成手性金属有机-框架化合物.%By postsynthetic modification method (PSM),chiral metal-organic frameworks (MOFs) were designed and synthesized,The L-proline derivative (Boc-L-ProCl) was anchored on the pore of Cr-MIL-101-NH2 by PSM method to gain a chiral MOFs (Cr-MIL-101-PaB2).1H NMR spectra confirmed the yield up to 64％ by twice process of PSM,and solid circular dichroism (CD) result showed that Cr-MIL-101-PaB2was a chiral compound.Their structures were characterized by infrared spectroscopy (IR),nitrogen desorption-adsorption,thermogravimetry (TGA),powder X-ray diffraction (PXRD).The experimental results confirmed that synthesized chiral MOFs by PSM method for the needed purpose can avoid the self-assembly uncertainty of MOFs.
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