A new ruthenium(Ⅱ) complex containing aliphatic polyamine [Ru(dipn)(tpy)](ClO4)2 (1), (tpy and dipn stand for 2,2′:6′2″-terpyridine and N-(3-aminopropyl)propane-l,3-diamine, respectively) was synthesized and characterized by EA, ESMS, UV-Vis and CV. The DNA-binding behaviors of this complex were studied by absorption titration, EB-competition fluorescence spectra and viscosity measurements, compared with those of it's series compounds [Ru(dipn)(dptp)](ClO4)2 (2) and [Ru(dipn)(pat)](ClO4)2 (3) (dptp=2-(5,6-diphenyl-1,2,4-triazin-3-yl)-1,10-phenanthroline; pat=9-(1, 10-Phenanthrolin-2-yl) acenaphtho[ 1,2-e][ 1,2,4]triazine). The results indicate that the three complexes interact with DNA in different mode: electrostatic attraction, partial intercalation and intercalation for 1, 2and 3, respectively. Their DNA affinities are in order: 1 ＜ 2 ＜ 3.%合成了1个含脂肪多胺的钌配合物[Ru(dipn)(tpy)](ClO4)2(1)(tpy和dipn分别代表2,2′:6′2″-三联吡啶和二丙三胺),用元素分析、电喷雾质谱、紫外-可见光谱及循环伏安进行了表征.采用电子吸收光谱滴定、EB竞争荧光光谱及粘度实验研究了该化合物与小牛胸腺DNA作用的性质,并与其系列化合物[Ru(dipn)(dptp)](ClO4)2(2)和[Ru(dipn)(pat)](ClO4)2(3)(dtp=5,6-二苯基-3-(2-邻菲咯啉基)-1,2,4-三嗪;pat=3-(2-邻菲咯啉基)-1,2,4-三嗪并[5,6-f]苊)作了对比.结果表明,3个化合物1、2、3分别以静电吸引、部分插入及插入作用的模式与DNA作用,与DNA的亲和力的相对大小为:1＜2＜3.
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