Objective:To explore the role of bioimpedance analysis ( BIA ) in assessing nutritional status in non - dialysis patients with chronic kidney disease ( CKD ). Methods: According to the CKD classification criteria, 64 non - diabetic patients with CKD stage 2 to 4 due to primary glomerulonephritis were included in the study. Exclusion criteria was overt proteinuria, hematuria, requiring erythropoietin or immunosuppressant treatment, being fever, bleeding, steroid treatment within one month prior to enrollment. BIA, direct anthropometric measurements and blood biochemical test was used to assess the nutritional status of these patients. Results: According to body mass index ( BMI ), 11 % of the patients were below normal. Blood biochemical test showed that no one of the patients had a level of serum albumin, pre - albumin, globumin, cholesterol below normal. , the percentage of patients with level of total protein, transferring, hemoglobin, triglyceride below normal was 2% ,2% ,17% and 2% , respectively. BIA showed that 52% patients had lean weight below normal; 86% patients had dry lean weight below normal. BIA detected significantly more patients below normal than other methods. Conclusion: BIA is a non - invasive and reproducible convenient method being able to earlier detect malnutrition status in non - diabetic CKD patients than standard methods.%目的:探讨生物电阻抗法人体成分测量在评价慢性肾脏病非透析患者营养状态中的作用.方法:选取门诊随访的原发病为肾小球肾炎的慢性肾脏病2～4期患者64例,排除糖尿病、大量蛋白尿、血尿、需要促红细胞生成素或免疫抑制剂治疗,以及近1月内有发热、消化道出血、使用类固醇激素者,采用人体生物电阻抗法人体成分测量、体重指数(BMI)和实验室检查等指标评价患者营养状态.结果:BMI显示11%的患者存在营养不良;实验室检查白蛋白均在正常范围内,球蛋白、前白蛋白与胆固醇均正常或高于正常,总蛋白、转铁蛋白、血红蛋白与三酰甘油低于正常的患者分别为2%,2%,17%,2%;生物电阻抗法检测显示52%的患者瘦体重低于正常,86%的患者干瘦体重低于正常,与其他指标相比差异有统计学意义(P<0.01).结论:生物电阻抗法人体成分测量可更早发现慢性肾脏病早中期患者营养不良,具有无创、安全、可重复性强的优点,值得临床推广应用.
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