Objective To quantitatively analyze dynamic MR parameters of female normal adenohypophysis and prolactin-secreting pituitary microadenomas, and to explore the optimal diagnostic threshold of these parameters for prolactin-secre-ting pituitary microadenomas. Methods Dynamic enhanced MR imaging was performed in 30 normal female adenohypophysis and 30 patients with female prolactin-secreting pituitary microadenoma. The shape of time-signal intensity curve (TIC), the peak time, the slop and enhance rate were statistically compared between normal adenohypophysis and microadenomas, while the diagnostic threshold of prolactin-secreting pituitary microadeoma was determined with ROC, the sensitivity and specificity were calculated as well. Results Taking peak time of 66 s as the threshold of pituitary microadenoma, the diagnostic sensitivity and specificity was 76. 70% and 84. 40%. When the slop of enhancement curves of 2. 015 was taken as the threshold, the sensitivity and specificity was 88. 50% and 67. 10% , respectively. Taking combined peak time, slop and enhance rate of 0. 566 as the threshold, the sensitivity and specificity was 92. 20% and 87. 53%, respectively. Conclusion Peak time 66 s, slop of enhancement 2. 015 and combined peak time, slop and enhance rate 0. 566 can be regarded as the threshold of dynamic enhanced MR imaging in diagnosis of pituitary microadenoma.%目的 定量分析动态增强MRI诊断女性垂体泌乳素微腺瘤的各参数指标,探索各参数的最佳阈值.方法 分析30例女性垂体泌乳素微腺瘤及30名健康女性腺垂体动态增强MRI,比较泌乳素微腺瘤与正常腺垂体时间-信号强度曲线(TIC)的形态、达峰时间、强化率、强化斜率.采用ROC法确定垂体泌乳素微腺瘤的诊断阈值,并计算诊断敏感度、特异度.结果 当以达峰时间66 s作为诊断阈值时,其敏感度为76.70％,特异度为84.40％；以强化斜率为2.015作为诊断阈值时,其敏感度为88.50％,特异度为67.10％；达峰时间、强化率、强化斜率联合诊断的诊断点为0.566时,其敏感度92.20％,特异度87.53％.结论 可将动态增强MR扫描达峰时间66 s、强化斜率2.015及达峰时间、强化率、强化斜率联合诊断点为0.566作为诊断垂体泌乳素微腺瘤的参考阈值.
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