Objective: Our aim was to detect weather the functional connectivity between the orbitofrontal cortex (OFC) and other brain regions were impaired in type 2 diabetes mellitus (T2DM). Materials and Methods: Conventional magnetic resonance imaging (MRI) and blood oxygen level dependent resting-state functional MRI were obtained from 27 diabetic patients without cerebrovascular diseases on imaging, and from 21 age-matched healthy volunteers. The functional connectivity between the bilateral OFC and other voxels of the whole brain was calculated and compared between the two groups. The brain regions with significant differences between the groups were selected, then, the mean value of the functional connectivity between these regions was calculated. The correlations were analyzed with the clinical indexes. Results: Compared to the control group, the patients showed significantly reduced functional connectivity between the posterior of left medial OFC and left midbrain, right hypothalamus and bilateral thalamus. In the patients group, the mean value of functional connectivity between the posterior of left medial OFC and the left midbrain was positively correlated with the value of fasting plasma glucose (t=2.3727, P=0.028). Conclusions: The functional connectivity between the left OFC and multiple brain regions in patients with type 2 diabetes mellitus was impaired, and the reduced functional connectivity value between the left OFC and the left midbrain was significantly associated with the controlling of the plasma glucose, which indicated that type 2 diabetes mellitus may impaire some reward -related pathways, leading to eating disorders.%目的 探索2型糖尿病对眶额皮层与其它脑区之间的相关功能连接是否存在异常.材料与方法 对27名不伴有脑血管病变影像征象的2型糖尿病患者及21名正常志愿者进行常规MRI及静息态功能MRI扫描,计算双侧眶额皮层与全脑其它体素间的功能连接值,并进行组间比较,选取组间具有显著差异的脑区,并计算其功能连接的平均值,与临床指标做相关性分析.结果 与正常对照组相比,2型糖尿病患者左侧眶额皮层内侧后部与左侧中脑、右侧下丘脑、双侧丘脑的功能连接强度显著减低.其中2型糖尿病患者左侧眶额皮层内侧后部与左侧中脑之间的功能连接平均值与空腹血糖值存在正相关(t=2.3727,P=0.028).结论 2型糖尿病患者眶额皮层与多个脑区的功能连接存在异常,其中左侧眶额皮层内侧后部与左侧中脑之间的功能连接异常与血糖控制的好坏程度相关.说明2型糖尿病可能损伤了奖赏系统的相关通路,从而导致摄食紊乱.
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