Objective To explore the relationship between dynamic contrast-enhanced MRI (DCE-MRI) and DWI of prostate cancer, in order to evaluate the internal relationship between perfusion level of microcirculation and hyperblastosis of prostate cancer from imaging perspective. Methods Totally 53 prostate cancer patients confirmed with pathology underwent DCE-MRI using 3. 0T MR liver acquisition with volume acceleration (LAVA) and DWI. Signal intensity-time (SI-T) of cancerous and non-cancerous regions in peripheral prostate zone were acquired, and the time to minimum (Tmax), the whole enhancement degree (SImax) and the maximum slope (Rmax) were calculated. ADC in DWI was assessed, and the correlation to perfusion indexes in DCE-MRI was analyzed statistically. Results The value of Tmax, SImax, Rmax in cancerous and noncancerous regions was (17. 13 ± 3. 33) s, ( 1. 60 ± 0. 26) % , (9. 31 ± 2. 43) % and (34. 20 ± 11. 53) s, (1.20± 0.18)%, (4.00±1.52)%, respectively (t=-7. 85, 7.50, 13.38; all P<0.01). The ADC value in cancerous and non-cancerous regions was (0. 91 ± 0. 18) × 10-3 mm2/s and (1. 62 ± 0. 13) × 10-3 mm2/s, respectively (t=-21.82, P< 0. 01). There was positive correlation between Tmax and ADC (r=0. 53, P<0. 01) and negative correlation between SImax, Rmax and ADC (r= -0. 33, -0. 46, both P<0. 01) in cancerous regions of prostate cancer. Conclusion Perfusion indexes of DCE-MRI are correlated to ADC in prostate cancer. DCE-MRI combined with DWI might improve the accuracy of detection, localization and staging of prostate cancer.%目的 探讨前列腺癌诊断中动态对比增强MRI(DCE-MRI)灌注指标与DWI ADC值的相关性,从影像学角度评估前列腺癌微循环灌注水平与癌组织增殖的关系.方法 对经组织病理学证实的53例前列腺癌患者行肝脏快速容积采集序列(LAVA)动态增强扫描和DWI检查,获得双侧外周带癌区与非癌区信号强度-时间(SI-T)曲线,计算达峰时间(Tmax)、最大强化程度(SImax)、最快强化率(Rmax)和ADC值,分析DCE-MRI灌注指标与ADC值之间的相关性.结果 前列腺癌患者癌区和非癌区Tmax、SImax、Rmax分别为(17.13±3.33)s、(1.60±0.26)％、(9.31±2.43)％和(34.20±11.53)s、(1.20±0.18)％、(4.00±1.52)％,二者差异均有统计学意义(t=-7.85、7.50、13.38,P均＜0.01)；癌区和非癌区ADC值分别为(0.91±0.18)×10-3mm2/s和(1.62±0.13)×10-3mm2/s,二者差异有统计学意义(t=-21.82,P＜0.01).前列腺癌癌区Tmax与ADC值呈正相关(r=0.53,P＜0.01),SImax和Rmax与ADC值均呈负相关(r=-0.33、-0.46,P均＜0.01).结论 前列腺癌DCE-MRI灌注指标与MR DWI ADC值具有相关性,两种技术联合应用有助于提高前列腺癌定位、定性及分期诊断的准确性.
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