目的 探讨瞬时波强(WI)技术在评价2型糖尿病(T2DM)合并周围神经病变(DPN)患者的颈动脉弹性中的临床应用价值.方法 收集88例T2DM患者,根据是否合并DPN分为A、B两组,A组43例为T2DM未合并DPN患者,B组45例为T2DM合并DPN患者；另选同期42名健康志愿者作为对照(C组).应用WI技术测量患者颈总动脉弹性的相关参数,并进行统计学分析.结果 A、B两组血管硬化参数(β)、血管压力应变弹性模量(Ep)、脉搏波传导速度(PWVβ)均高于C组(P均＜0.05)；B组β、Ep、PWVβ高于A组(P均＜0.05)；A组及B组瞬时加速度波强(W1)、瞬时减速度波强(W2)、血管顺应性(AC)低于C组(P均＜0.05)；B组W1、W2、AC低于A组(P均＜0.05).3组间负向波面积(NA)、管径面积(NAd)的差异均无统计学意义(P均＞0.05).结论 WI技术可以便捷、无创地评价T2DM合并DPN患者颈动脉弹性的异常改变.%Objective To assess the clinical value of wave intensity (WI) in estimating the carotid artery wall elasticity in patients of type 2 diabetes (T2DM) mellitus with diabetic peripheral neuropathy (DPN). Methods Eighty-eight T2DM patients were divided into group A (T2DM without DPN, n = 43) and B (T2DM with DPN, n = 45). Forty-two healthy subjects were enrolled as controls (group C). WI was used to measure the elasticity parameters of carotid artery, and the results were compared statistically. Results The vascular sclerosis parameters (β), vascular pressure strain elastic modulus (Ep) and pulse-wave velocity (PWVβ) in group A and B were significantly higher than those of group C (all P<0. 05). Β, Ep, PWVβ in group B were significantly higher than in group A (all P<0. 05). The accelerating wave intensity (WI), decelerating wave intensity (W2) and arterial compliance (AC) in group A and B were significantly lower than in group C (all P<0. 05). W1, W2, AC in group B were significantly lower than group A (all P<0. 05). There was no statistical difference of the negative area (NA) nor negative area diameter (Nad) among 3 groups (all P>0. 05). Conclusion WI can evaluate the elasticity of carotid artery in T2DM patients with or without DPN conveniently and non-invasively.
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