Purpose This study was aimed at investigating and contrasting the effects of Losartan, Fosinopril and Nifedipine GITS on cardiac structure and function in patients with essential hypertension (EH). Methods Eighty-seven patients with mild to moderate EH were randomly divided into three groups and were treated with Nifedipine GITS 30mg/d (n=29), Fosinopril 10mg/d (n=28) or Losartan 50mg/d (n=30) separately. Cardiac structure and function were measured with echocardiography before and after treatments of 4 and 16 weeks. Results The antihypertensive effects of three medicines had no statistical differences. Left ventricular diastolic function was improved at the end of 4 weeks (P<0.05～0.001). Left ventricular hypertrophy was regressed after 16 weeks treatment. The regression in F group was the largest and that in N group the smallest (P<0.05). Conclusion Three antihypertensive drugs all can significantly and safely decrease blood pressure, had strong effects on reversing ventricular hypertrophy, improve left ventricular diastolic function in early stage of hypertension.%目的 探讨氯沙坦、福辛普利和硝苯地平控释剂对高血压病患者心脏结构、血流及功能的影响，并进行比较。方法 87例轻中度高血压病患者随机分为3组，分别应用氯沙坦50mg/d(L组，30例) 、福辛普利10mg/d(F组，28例) 和硝苯地平控释剂30mg/d(N组，29例)， 应用超声心动图(UCG)，观察比较治疗前、治疗4周末及16周末诊所血压（CBP），心脏功能及左室心肌肥厚的逆转情况。结果 高血压病各组不良反应发生率分别为L组18.2%、F组39.4%、N组43.8%。治疗4周后CBP均有显著性降低，三组间无显著性差异，以硝苯地平控释剂组作用显著。16周末各组总有效率均达85%以上。4周末各组左室舒张功能均显著改善(P<0.05～0.001)。16周末各组左室肥厚逆转，以福辛普利与氯沙坦组作用显著(P<0.05)。结论 氯沙坦、福辛普利和硝苯地平控释剂均能有效持续地降低血压，改善高血压病早期的左室舒张功能损害。
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