This paper presents a new pulse oximeter used to low perfusion at 0.125%and wide oxygen saturation range from 35%to 100%. In order to acquire the best PPG signals, the variable gain amplifier(VGA) is adopted in hardware. The self-developed auto-correlation modeling method is adopted in software and it can extract pulse wave from low perfusion signals and remove motion artifacts partly.% 设计了一种能在低灌注和低血氧条件下准确测量的脉搏血氧仪，将低灌注检测能力和SpO2的测量范围分别扩展至0.125%和35%~100%。在硬件方面使用数字可控的可变增益放大器来获得最佳的光电容积图信号；在软件方面使用了自主开发的自相关建模法的低灌注SpO2测量算法，能有效从低灌注信号中提取脉搏波信号，且对运动干扰也有一定的抑制能力。
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