Objective: To study the therapeutic effect of Jiayanxiao (JYX) on thyrotoxic exophthalmos. Methods: Forty-three patients were divided randomly into two groups, the 31 Patients in the treated group were treated with JYX plus tapazole, and the 12 patients in the control group were treated with prednisone plus tapazole. The therapeutic course of both groups was 3 months. The symptoms, eye signs, thyroxin level, and other routine laboratory parameters as well as the adverse effect of the therapy were observed and compared between two groups. Results: The total effective rate in the treated group was 80.6%, which was obviously higher than that in the control group (50.0%, P＜0.05). Effect of the treated group in lowering degree of exophthalmos was superior to that of the control group. Effects in elevating vision, decreasing palpebral fissure altitude and lowering serum T3, T4 contents in the two groups were similar (P＞0.05). Moreover, the treated group showed better efficacy in improving clinical symptoms with less adverse effect. Conclusion: The therapeutic effect of JYX in treating thyrotoxic exophthalmos is ensured.
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