Objective:To analyze the clinical effect of injecting Ginkgo leaf extract and dipyridamole,together with internal and external treatment of traditional Chinese medicine in chronic obstructive pulmonary disease (COPD)combined with blood hyperviscosity.Method:Eighty-eight cases of COPD combined with blood hyperviscosity were divided in-to the intervention group (n=44)and the control group (n=44).The control group received conventional western medication treatment.And the intervention group received inj ecting Ginkgo leaf extract and dipyridamole,and inter-nal/external treatment of traditional Chinese medicine on the basis of the conventional medication.After 14 days, clinical effects and hemodynamic changes were compared between two groups.Results:14 days after treatment,the cure rate in the intervention group was significantly higher than that in the control group (45.45% vs 25.00%,re-spectively,P<0.05).The inefficiency rate in the intervention group was significantly lower than that in the control group (6.82% vs 22.73%,respectively,P<0.05).Within the intervention group,the indices of blood rheology , including high viscosity,low shear viscosity,hematocrit,plasma viscosity,fibrinogen and erythrocyte aggregation index,were significantly improved after treatment (P<0.01).All the indices of blood rheology after treatment in the intervention group,except the red cell aggregation index,decreased significantly compared with the control group (P<0.05).Conclusion:Injecting Ginkgo leaf extract and dipyridamole,together with internal and external treatment of traditional Chinese medicine in the treatment of high blood viscosity with COPD can significantly im-prove the clinical cure rate and the state of blood rheology.%目的：观察银杏达莫注射液联合内服外敷中药治疗慢性阻塞性肺疾病(简称慢阻肺,COPD)合并高黏血症的临床疗效。方法：88例COPD合并高黏血症患者分为治疗组(n=44)与对照组(n=44),对照组给予西医常规治疗,治疗组在对照组治疗的基础上,给予静脉滴注银杏达莫注射液,并予以中药内服和穴位贴敷。14天后观察两组临床疗效及血液流变学指标变化。结果：连续治疗14天后,治疗组临床痊愈率明显高于对照组(45.45%vs25.00%,P<0.05),无效率显著低于对照组(6.82%vs22.73%,P<0.05)。治疗组高切表观黏度、低切表观黏度、红细胞压积、血浆黏度、血浆纤维蛋白原含量和红细胞聚集指数等指标均较治疗前明显改善(P<0.01)；治疗组与对照组治疗后比较,除红细胞聚集指数外,其它指标均显著降低,差异有统计学意义(P<0.05)。结论：银杏达莫注射液联合内服外敷中药治疗COPD合并高黏血症,可明显提高临床痊愈率并显著改善血液流变状态。
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