Angiogenesis is characterized by forming new blood vessels from existing capillaries , and is mutually regulated by angio-genic factors and antiangiogenic factors in a dynamically balanced process .As a severely debilitating pathological change of a variety of diseases, including tumor, retinopathy of prematurity and diabetic retinopathy , etc, angiogenesis is a severely disabling condition . Thus, establishing animal models of neovascularization is an important prerequisite to study the pathogenesis .This article reviewed 4 animal models of angiogenesis , that is, aortic ring assay, matrigel plug assay, oxygen-induced retinopathy and laser-induced choroidal neovascularization in animal models .%新生血管是指从已有毛细血管发展形成新血管，该过程受血管生成因子和血管抑制因子双重调控，是一个动态平衡的过程。新生血管是多种疾病的病理性改变，包括肿瘤、早产儿视网膜病变和糖尿病视网膜病变等，是严重的致残性病变。建立新生血管动物模型是研究这些疾病发病机制的重要前提，本文主要对主动脉环血管生成模型、基质胶栓动物模型、氧诱导视网膜病变模型、激光诱导脉络膜新生血管动物模型4种建模方法进行了综述。
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