白念珠菌是一种重要的条件致病菌，多在体表及黏膜宿主共栖生存，可引起皮肤黏膜及内脏的广泛感染。白念珠菌是单细胞假菌丝酵母菌，形态上具有双相性，即菌丝相和孢子相。其中菌丝相更易黏附和入侵宿主组织，是该菌在体内的主要致病形式。白念珠菌的致病机制与多种因素如黏附、芽管、水解酶、生物膜、群体感应等有关。该文综述了白念珠菌致病机制的研究新进展。%Candida albicans is one of the most common fungal pathogens of humans that colonize the skin and mucosal surfaces of the healthy hosts.Candidaalbicans can cause the widespread infection in the skin mucous membrane and viscera of the hosts.This mi⁃croorganism is the single cell pseudohyphae yeast,which can grow as both of yeast and filamentous forms in the host,and viscerarmed fungal dimorphism or,more precisely,fungal polymorphism.The relative attributes of the yeast and filamentous forms of Candida albi⁃cans,during the colonization of skin and mucosa,and later in the invasion of the blood stream and deep tissues,had long been deba⁃ted.The pathogenesis of Candida albicans had been attributed to multi⁃factors,including adherence to host cells,secretion of degrada⁃tive enzymes,morphology switching,successful biofilm formation,quorum sensing and so on.In this paper,the recent research progress in the pathogenesis of Candida albicans was reviewed.
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