目的 初步探讨应用乳杆菌活菌胶囊在治疗妊娠期复发性念珠菌性阴道炎中的作用.方法 将2009年12月～2011年12月共266例在我院产科门诊就诊的妊娠期复发性念珠菌性阴道炎患者随机分为试验组和对照组,试验组给予克霉唑联合中药及乳杆菌活菌胶囊治疗,对照组仅给予克霉唑联合中药治疗,观察采用乳杆菌活菌胶囊调节阴道内微环境后的临床疗效,远期自愈率及复发率.结果 两组的近期治愈率相似,近期治疗效果分布无显著性差异(P＞0.05),但给予乳酸杆菌活菌胶囊治疗远期自愈率28.57％明显高于对照组,远期复发率为11.03％,明显低于对照组的26.92％,分娩时复发率(10.29％)明显低于对照组(29.23％),两者比较有显著地统计学意义(P＜0.05).结论 克霉唑联合中药及乳杆菌活菌胶囊治疗妊娠期复发性念珠菌性阴道炎临床效果好,远期自愈率高,复发率低,副反应小.%Objective To investigate the therapeutic effects of lactobacillus vaginal capsules for adjustment of vaginal microenvi-ronment in the treatment of pregnancy recurrent valvovaginal candidiasis. Methods Total 266 outpatients of pregnancy recurrent val-vovaginal candidiasis from December 2009 to December 2011 in our hospital were divided into experimental group and control group by random principle. The patients of experimental group took lactobacillus vaginal capsules and the antifungal treatment by clotrima-zole suppository combined with traditional Chinese medicine ; the patients of control group took only clotrimazole suppository combined with traditional Chinese medicine. The clinical effects, the rates of long-term self-healing ,the long-term recurrence and the recurrence rates during delivery after the end of treatment were observed. Results The short term cure rates of the two groups were similar ( P >0.05) , however, there was statistic differences in the rates of long-term self-healing , the long-term recurrence rates and the recurrence rates during delivery after the application of lactobacillus vaginal capsules on experimental group ( P <0.05). The rate of long-term self-healing was 28.57% in experimental group,which was significantly higher than that in control group and the long-term recurrence rate was 11. 03% in experimental group, which was significantly lower than that in control group (26. 92% ) and the recurrence rate during delivery after treatment was 10. 29% in experimental group, which was significantly lower than that in control group (29.23% ). Conclusion Adjustment of vaginal microenvironment with application lactobacillus vaginal capsules and the antifungal treatment by clotrimazole suppository combined with traditional chinese medicine have good therapeutic effects on the treatment of pregnancy recurrent valvovaginal candidiasis, with high self-healing rate, low rate of recurrence and little side reaction.
展开▼
