Angiotensin Ⅱ receptor antagonists (ARB) are antihypertensive drugs blocking the renin-angiotensin system.Growing evidence proved ARB had kidney protective effect besides the role on proteinuria.Being different from antihypertensive drugs with other mechanisms,ARB could exert kidney protective effect through multiple pathways and is widely used in patients with chronic kidney disease,hypertension or diabetes.This review focuses on proteinuria-lowing and kidney protective mechanism of ARB,and provides an update about clinical practice.%血管紧张素Ⅱ受体拮抗剂(ARB)是一类作用于肾素-血管紧张素系统的降压药物,越来越多的证据表明ARB不仅能降低患者蛋白尿水平,且兼具肾脏保护作用.ARB有别于其降压机制,可通多种途径发挥肾脏保护作用,临床广泛应用于慢性肾脏病、高血压、糖尿病等多种疾病领域.本文就ARB降低蛋白尿及肾脏保护机制及临床实践相关进展做一综述.
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