目的 评价中度有氧运动对阿尔茨海默病患者的干预效果.方法 检索相关中英文数据库,收集有氧运动对阿尔茨海默病患者干预效果的随机对照试验,利用RevMan 5.2.0软件进行统计处理.结果 纳入文献8篇,中度有氧运动能够提升阿尔茨海默病患者简易精神状态评分(WMD=1.58,95%CI:0.63~2.53,P<0.01),降低阿尔茨海默病认知功能评定量表评分(WMD=-4.06,95%CI:-6.83~-1.28,P<0.01)和精神行为症状问卷评分(WMD=-3.97,95%CI:-5.69~-2.25,P<0.01).结论 适当的有氧运动能够提升阿尔茨海默病患者的认知功能,改善其精神行为症状.%Objective To evaluate the effectiveness of moderate aerobic exercise intervention for patients with Alzheimer's disease. Methods Randomized Clinical Trials(RCTs) that assessed the effectiveness of aerobic exercise intervention for patients with Alzheimer's disease were reviewed using multiple electronic databases systematically. Data were analyzed by RevMan 5.2.0 version. Results Eight RCTs were included. Meta-analysis indicated that moderate aerobic exercise could improve the score of MMSE(WMD=1.58,95%CI:0.63~2.53,P<0.01),reduce the score of Alzheimer's disease assessment scale-cognitive subscale(ADAS-Cog)(WMD=-4.06,95%CI:-6.83~-1.28,P<0.01) and the score of Neuropsychiatric Inventory(WMD=-3.97,95%CI:-5.69~-2.25,P<0.01). Conclusion Moderate Aer-obic exercise can improve cognitive function of Alzheimer's patients,and improve their neuropsychiatric symptoms.
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