Free radical scavenging abilities of polypeptide from Chlamys farreri

HAN Zhiwu; CHU Xiao; LIU Chengjuan; WANG Yuejun; SUN Mi; WANG Chunbo

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Free radical scavenging abilities of polypeptide from Chlamys farreri

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We investigated the radical scavenging effect and antioxidation property of polypeptide extracted from Chlamys farreri (PCF) in vitro using chemiluminescence and electron spin resonance (ESR) methods. We examined the scavenging effects of PCF on superoxide anions (O-2), hydroxyl radicals (OH·), peroxynitrite (ONOO-) and the inhibiting capacity of PCF on peroxidation of linoleic acid. Our experiment suggested that PCF could scavenge oxygen free radicals including superoxide anions (O-2) (IC50 =0.3 mg/ml), hydroxyl radicals (OH·) (IC50 = 0.2 μg/ml) generated from the reaction systems and effectively inhibit the oxidative activity of ONOO- (IC50 = 0.2 mg/ml). At 1.25 mg/ml of PCF, the inhibition ratio on lipid peroxidation of linoleic acid was 43 %. The scavenging effect of PCF on (O-2), OH·and ONOO- free radicals were stronger than those of vitamin C but less on lipid peroxidation of linoleic acid. Thus PCF could scavenge free radicals and inhibit the peroxidation of linoleic acid in vitro. It is an antioxidant from marine products and potential for industrial production in future.

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《中国海洋湖沼学报（英文版）》 |2006年第3期|325-328|共4页
作者
HAN Zhiwu; CHU Xiao; LIU Chengjuan; WANG Yuejun; SUN Mi; WANG Chunbo;
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作者单位

Affiliated Hospital of Medical School,Qingdao University,Qingdao 266003,China;

Affiliated Hospital of Medical School,Qingdao University,Qingdao 266003,China;

Affiliated Hospital of Medical School,Qingdao University,Qingdao 266003,China;

Research Institute of Yellow Sea Aquatic Products,Qingdao 266032,China;

Research Institute of Yellow Sea Aquatic Products,Qingdao 266032,China;

Research Institute of Yellow Sea Aquatic Products,Qingdao 266032,China;

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原文格式 PDF
正文语种 chi
中图分类海洋学;
关键词
polypeptide; Chlamys farreri; free radical; antioxidant; chemiluminescence; electron spin resonance (ESR);

机译：多肽;衣原体;自由基;抗氧化剂;化学发光;电子自旋共振（ESR）;

Free radical scavenging abilities of polypeptide from Chlamys farreri

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