The tyrosinase gene family and albinism in fish

WANG Jiaqing; HOU Lin; ZHANG Ruifeng; ZHAO Xintao; JIANG Lijuan; SUN Wenjing; AN Jialu; LI Xiaoyan

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The tyrosinase gene family and albinism in fish

机译：鱼中酪氨酸酶基因家族和白化病

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摘要

Tyrosinase exists universally in organisms and is a characterstic enzyme of melanocytes.Tyrosinase family genes in vertebrates consist of 3 related members; tyrosinase (TYR, Tyr),tyrosinase-related protein-1 (TRP-1, Tyrpl), and tyrosinase-related protein-2 (TRP-2, Tyrp2, Dct). These proteins catalyze melanin biosynthesis in pigment cells and play important roles in determining vertebrate coloration. Transcription of the TYR and TRP genes is useful for studying neural crest and optic vesicle cell migration and differentiation during embryogenesis and important in pigment rescue in fish. In this paper, the structure of gene and protein molecular evolution, function and roles of the TYR family in fish were reviewed.

机译：酪氨酸酶在生物体中普遍存在，是黑素细胞的特征性酶。脊椎动物的酪氨酸酶家族基因由3个相关成员组成。酪氨酸酶（TYR，Tyr），酪氨酸酶相关蛋白1（TRP-1，Tyrpl）和酪氨酸酶相关蛋白2（TRP-2，Tyrp2，Dct）。这些蛋白质催化色素细胞中黑色素的生物合成，并在确定脊椎动物的着色中起重要作用。 TYR和TRP基因的转录可用于研究胚胎发生过程中神经rest和视泡细胞的迁移和分化，并且对鱼的色素拯救非常重要。本文综述了鱼类中TYR家族的基因和蛋白质分子进化结构，功能和作用。

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来源
《中国海洋湖沼学报（英文版）》 |2007年第2期|191-198|共8页
作者
WANG Jiaqing; HOU Lin; ZHANG Ruifeng; ZHAO Xintao; JIANG Lijuan; SUN Wenjing; AN Jialu; LI Xiaoyan;
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作者单位

College of Life Science,Liaoning Normal University,Dalian 116029,China;

College of Life Science,Liaoning Normal University,Dalian 116029,China;

College of Life Science,Liaoning Normal University,Dalian 116029,China;

College of Life Science,Liaoning Normal University,Dalian 116029,China;

College of Life Science,Liaoning Normal University,Dalian 116029,China;

College of Life Science,Liaoning Normal University,Dalian 116029,China;

College of Life Science,Liaoning Normal University,Dalian 116029,China;

College of Life Science,Liaoning Normal University,Dalian 116029,China;

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收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
原文格式 PDF
正文语种 chi
中图分类动物学;
关键词
fish; tyrosinase gene family; molecular evolution; transgene; albinism;

机译：鱼;酪氨酸酶基因家族;分子进化;转基因;白化病;

The tyrosinase gene family and albinism in fish

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