Objective To observe microangium abnormality characteristics of nasopharyngeal carcinoma (NPC).Methods Using the contact microendoscope and digital video image system, the microangium of the focus and perifocal mucosa was observed in vivo.Results In an overwhelming majority of NPC cases, the nasopharyngeal mucosa microangium was crooked, with an irregular vascular diameter, very fragile and easy to bleed. We observed 126 cases of NPC, 1154 cases of other nasopharyngeal disorders as well as 30 cases of normal control. The abnormality of the microangium could be divided into 4 degrees by analyzing the results. Most NPC cases (85%) had microangium abnormality of degree 3. In contrast, most nasopharyngeal inflammation cases and normal controls presented microangium abnormality of degree 0 to degree 1.Conclusion Microangium abnormality is one of the pathologic and clinical characteristics in NPC, and it could become one of the microendoscopic parameters in an early diagnosis of NPC.%目的观察研究鼻咽癌微血管异常的特征。方法应用接触式显微内窥镜配合特别装配的数字视频图像系统，对活体鼻咽癌病灶及癌旁粘膜表面微血管形态进行观察研究。结果绝大多数鼻咽癌病灶表面存在具特征性的微血管异常，即微血管增生、曲张、迂回扭曲、管径粗细不均、浅表脆弱、易出血。通过对126例鼻咽癌病人及1154例其它鼻咽病变和正常对照组的检查结果分析，将微血管异常程度分为4级，鼻咽癌病灶微血管异常3级者为85%，2级为12%，1级为3%；鼻咽炎病人3级为0，2级为8%，1级为82%，0级为10%；正常对照者1级42%，0级58%。鼻咽囊肿及鼻咽血管纤维瘤等病例也有不同程度的微血管扩张或曲张，但不如鼻咽癌典型。结论微血管增生异常是鼻咽癌具有特征性的一项病理与临床表现，可作为显微内窥镜早期诊断鼻咽癌的观察指标之一。
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