@@ 因进入体内会导致海马、前额叶皮层、中脑腹侧被盖区及伏隔核等学习记忆相关脑区的多巴胺、谷氨酸、5-羟色胺(5-hydroxytryptamine,5-HT)等神经递质释放的异常变化,通过作用于相应的受体引发一系列分子事件: 包括激活细胞内信号转导通路,改变神经营养因子、转录因子、即刻早期基因或染色体的结构等, 并最终引起突触的可塑性, 甚至神经元的形态结构发生变化,从而导致成瘾形成.%Cocaine addiction involves a variety of complex mechanisms, including neural, transcriptional and signal transductional processes. In recent years, many studies have shown that some microRNAs can weaken the rewards of drug effect and suppress the formation of cocaine addiction. On the other hand, some microRNAs, such as ADICD microR-Nas, contribute to cocaine addiction. Therefore, regulating the transcriptional levels of these microRNAs and the expression of their targeting genes may provide a new approach for the treatment of cocaine addiction. This article reviews the structure and function of microRNAs involved in cocaine addiction and the relationship between microRNAs and cocaine addiction.
展开▼
